Results 61 to 70 of about 578,669 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Unified Synthesis Approach for High-Selectivity LP-/HP-/BP-Filtering Amplifiers Using Extracted-Pole Matching Filters

IEEE Access
This paper introduces a novel and generalized synthesis approach for realizing highly selective filtering amplifiers (FAs) based on a new type of Extracted-Pole Matching Filter (EPMF).
Di Lu, Menghan Sun, Jiajun Cai, Baoqi Zhu, Yang Wu, Yang Gao, Ming Yu   +6 more
doaj   +1 more source

One-year grazing exclusion remarkably restores degraded alpine meadow at Zoige, eastern Tibetan Plateau

Global Ecology and Conservation, 2020
Understanding the influences of grazing exclusion (GE) on soil properties and vegetation characteristics is essential for the assessment of grassland restoration.
Miao Liu, Zhenchao Zhang, Jian Sun, Yi Wang, Jinniu Wang, Atsushi Tsunekawa, Mesenbet Yibeltal, Ming Xu, Youjun Chen   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization Controller Design of Full-Vehicle Suspension System Based on Bicubic Positive-Real Impedances Realizable with Five Passive Elements

Actuators
This article investigates the passive controller design problem for a full-vehicle suspension system, where the passive controller consists of four positive-real bicubic impedances realizable as two-terminal five-element damper–spring–inerter networks ...
Kai Wang, Yaodong Li, Jiamei Pu
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dynamics and Drivers of the Alpine Timberline on Gongga Mountain of Tibetan Plateau-Adopted from the Otsu Method on Google Earth Engine

Remote Sensing, 2020
The alpine timberline, an ecosystem ecotone, indicates climatic change and is tending to shift toward higher altitudes because of an increase in global warming.
Wen He, Chongchong Ye, Jian Sun, Junnan Xiong, Jinniu Wang, Tiancai Zhou   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reversible Deactivation Radical Polymerization: From Polymer Network Synthesis to 3D Printing. [PDF]

Adv Sci (Weinh), 2021
Bagheri A, Fellows CM, Boyer C.
europepmc   +1 more source