Results 31 to 40 of about 82,373 (261)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Network Traffic Characteristics Reconstruction Method for Mitigating the Impact of Packet Loss in Edge Computing Scenarios

Future Internet
This paper presents TCReC, an innovative model designed for reconstructing network traffic characteristics in the presence of packet loss. With the rapid expansion of wireless networks driven by edge computing, IoT, and 5G technologies, challenges such ...
Jiawei Ye, Yanting Chen, Aierpanjiang Simayi, Yu Liu, Zhihui Lu, Jie Wu   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A Multi-Branched Hybrid Perceptron Network for DDoS Attack Detection Using Dynamic Feature Adaptation and Multi-Instance Learning

IEEE Access
The increasing sophistication and frequency of Distributed Denial of Service (DDoS) attacks necessitate advanced detection systems. These attacks leave networks vulnerable to disruptions, resource overload, security breaches, and financial losses ...
Ali Tariq Kalil Al-Khayyat, Osman Nuri Ucan   +1 more
doaj   +1 more source

A Review on Internet Traffic Classification Based on Artificial Intelligence Techniques

International Journal of Information and Communication Technology Research, 2022
Almost every industry has revolutionized with Artificial Intelligence. The telecommunication industry is one of them to improve customers' Quality of Services and Quality of Experience by enhancing networking infrastructure capabilities which could lead ...
Mohammad Pooya Malek, Shaghayegh Naderi, Hossein Gharaee Garakani   +2 more
doaj  

Critical Traffic Analysis on the Tor Network

Journal of Cyber Security and Mobility, 2020
Tor is a widely-used anonymity network with more than two million daily users. A prominent feature of Tor is the hidden service architecture. Hidden services are a popular method for communicating anonymously or sharing web contents anonymously.
Florian Platzer, Marcel Schäfer, Martin Steinebach   +2 more
openaire   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A Transformer-Based Framework for DDoS Attack Detection via Temporal Dependency and Behavioral Pattern Modeling

Algorithms
With the escalating global cyber threats, Distributed Denial of Service (DDoS) attacks have become one of the most disruptive and prevalent network attacks.
Yi Li, Xingzhou Deng, Ang Yang, Jing Gao
doaj   +1 more source