Results 61 to 70 of about 735,266 (340)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Multipath transmission control protocol–based multi-access traffic steering solution for 5G multimedia-centric network: Design and testbed system implementation

open access: yesInternational Journal of Distributed Sensor Networks, 2020
Various technologies have been developed for the efficient use of the multiple radio access technologies resource at the radio access network level or other network levels to improve user service quality in mobile communication networks.
Yoohwa Kang   +3 more
doaj   +1 more source

DRACULA Microscopic Traffic Simulator [PDF]

open access: yes, 1994
The DRACULA traffic simulator is a microscopic model in that the vehicles are individually represented. The movement of vehicles in the network are represented continuously and updated every one second.
Liu, R.
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Traffic Control for Network Protection Against Spreading Processes [PDF]

open access: yes, 2013
Epidemic outbreaks in human populations are facilitated by the underlying transportation network. We consider strategies for containing a viral spreading process by optimally allocating a limited budget to three types of protection resources: (i) Traffic
Preciado, Victor M.   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

Integration of Regional Demand Management and Signals Control for Urban Traffic Networks

open access: yesIEEE Access, 2019
Many efforts have been focused on the network-wide traffic signal optimization to deal with the congestion problem in big cities. Nevertheless, research evidence illustrates that both improper traffic network managements and excessive traffic demands are
Zhao Zhou   +3 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy