Results 151 to 160 of about 25,349 (316)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Networked control systems with sampling interval adaptation
, 2018 Networked control systems (NCSs) are distributed control system where the sensors, actuators and controllers are physically separated and connected through communication networks.
Porto, Arthur José Vieira +1 more
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Modeling and Control of Networked Control Systems with Bounded Delay and Packet Disordering
, 2010 In this paper, modeling and stabilization of networked control systems are discussed. Considering the existence of packet disordering in information transmission, a new mathematical model is proposed to describe the dynamical characteristics of networked
Li JN(李金娜) +3 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Output Tracking-based H(infinity) Control of Networked Control Systems with Packet Disordering
, 2010 This paper is concerned with H(infinity) output tracking control of networked control systems with packet disordering. Considering random and bounded delay and packet disordering, a mathematical model of networked control systems is proposed by ...
Dang XD(党向东) +3 more
core
Robust fault detection for networked systems with communication delay and data missing
, 2009 n this paper, the robust fault detection problem is investigated for a class of discrete-time networked systems with unknown input and multiple state delays.
He, X, Wang, Z, Zhou, DH
core +1 more source
Super-Resolution Reconstruction Method of Face Image Based on Attention Mechanism
IEEE AccessIn recent years, convolutional neural network in Single image super-resolution field show good results. Deep networks can establish complex mapping between low-resolution and high-resolution images, making the reconstructed images quality a great ...
Chenglin Yu, Hailong Pei
doaj +1 more source