Results 241 to 250 of about 3,955,010 (358)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. [PDF]

Front Immunol
Pine A, Butt A, Andreoli L, Knight JS, Gerosa M, Cecchi I, Branch DW, Lopez-Pedrera R, Belmont HM, Kello N, Petri M, Cervera R, Pengo V, Meroni PL, Cohen H, Willis R, Bertolaccini ML, Goshua G, Gu S, Hwa J, Lee AI, Erkan D, Sharda AV.   +22 more
europepmc   +1 more source

Mobility-Aware Caching in D2D Networks [PDF]

, 2016
Rui Wang, Jun Zhang, Shenghui Song, Khaled B. Letaief   +3 more
openalex   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Correction to "Psychological and motivational factors associated with addiction tendencies to gaming, video viewing, and social networking services use among high school students: a cross-sectional study". [PDF]

PCN Rep
europepmc   +1 more source

Shifting Focus: An Advocacy-Focused Analysis of Omega Beta Iota's Membership and Political Engagement Strategies. [PDF]

Cureus
Rashid MF, Rizvi SA.
europepmc   +1 more source

Building Bayesian Neural Networks with Blocks: On Structure, Interpretability and Uncertainty [PDF]

, 2018
Hao Zhou, Yunyang Xiong, Vikas Singh
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimizing Cryo-Focused Pyrolysis GC/MS for Tracing Soil Organic Matter Across Diverse Ecosystems. [PDF]

Environ Sci Technol
Shahriar A, Zavarin M, Nuccio EE, Grant KE, McFarlane KJ, Pett-Ridge J, Toews D, Sexton JP, Ryals R, Baccei J, Berndt AJ, Boiteau R, Jawad IA, Yang Y, Bansal S, O'Loughlin EJ, Kemner KM, Matamala R, Morrison KD.   +18 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source