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Neural cell adhesion molecule expression in thyroid cancer
Oncology Reports, 1996Neural cell adhesion molecule (NCAM) is an integral membrane glycoprotein that participates in cell-cell interactions. We examined the expression of neural cell adhesion molecule (NCAM) by immunohistochemistry in 65 cases of thyroid disease. In the majority of thyroid tumors, NCAM expression was detected in tumor cells.
Minoru Hirano +6 more
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The neural cell adhesion molecule NCAM in multiple myeloma
Leukemia & Lymphoma, 1996The Neural Cell Adhesion Molecule NCAM is a membrane glycoprotein and belongs to the immunoglobulin superfamily. It is expressed on neural cells as well as on various neuroendocrine tumors and can be detected in sera of patients with small cell lung cancer. Its role is attributed to tumor invasion and formation of metastases. Malignant plasma cells and
Marcus Oldenburg +2 more
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Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders
European Journal of Pharmacology, 2000Cell adhesion molecule proteins play a diverse role in neural development, signal transduction, structural linkages to extracellular and intracellular proteins, synaptic stabilization, neurogenesis, and learning. Three basic mRNA isoforms and potent posttranslational modifications differentially regulate these neurobiological properties of the neural ...
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Gene regulation of cell adhesion molecules in neural morphogenesis
Acta Paediatrica, 1997A mounting body of evidence suggests that cell‐cell adhesion molecules (CAMs) play critical roles in morphogenetic patterning and in laying down the initial tissue scaffold of the nervous system. Perturbations of CAM binding can lead to altered tissue pattern and interruption of tissue interactions to altered patterns of CAM expression.
Gerald M. Edelman, Frederick S. Jones
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The neural cell adhesion molecule in synaptic plasticity and ageing
International Journal of Developmental Neuroscience, 2000AbstractBy mediating cell adhesion and signal transduction, the neural cell adhesion molecule (NCAM) regulates neurite outgrowth, fasciculation and target recognition in the developing nervous system. In addition, a number of studies suggest an important role for the NCAM in regeneration and learning in the adult nervous system. NCAM‐deficient mice are
Lars Christian B. Rønn +2 more
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Neural cell adhesion molecule expression in Xenopus embryos
Developmental Biology, 1987The spatiotemporal pattern of expression of the neural cell adhesion molecule NCAM was mapped immunohistochemically in embryos of the frog Xenopus, from blastula to early swimming stages, using a polyclonal antibody that recognizes Xenopus NCAM. The neural plate stage was the earliest at which NCAM could be detected.
Marcus Jacobson +3 more
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Neural Cell Adhesion Molecule as a Regulator of Cell-Cell Interactions
1990Progress in the investigation of cell-cell interactions in tissue formation has been particularly rapid in recent years (for review see Rutishauser and Jessell, 1988). A fundamental hypothesis throughout this work has been that these interactions reflect specific molecular complementarity mediated by distinct components at the cell surface. In addition,
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The Neural Cell Adhesion Molecule NCAM and Lipid Rafts
2009Detergent-resistant membrane microdomains, the so-called lipid rafts, are involved in a wide array of cellular processes including membrane trafficking and intracellular signalling. In connection with the increased interest in lipid rafts, these structures have been reported in a number of studies to be of critical importance for signalling processes ...
Dorte Kornerup Ditlevsen +1 more
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Regulation of neural cell adhesion molecule sialylation state
International Journal of Biochemistry, 1991The neural cell adhesion molecule (NCAM) is a complex of three immunologically-related membrane polypeptides of 180, 140 and 120 kDa molecular weight (Hirn et al., 1983; Choung and Edelman, 1984; Sheehan et al., 1986). These isoforms are primary translation products which arise through the alternate splicing of a single gene located on human chromosome
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Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms
2009Neural cell adhesion molecule (NCAM) was initially characterized in cells of the nervous system, where its role in various neural processes is well established. However, NCAM is also expressed in a wide variety of non-neuronal cell types, where its function has been remained largely elusive. Importantly, the expression of NCAM appears to be deregulated
Silvia Zecchini, Ugo Cavallaro
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