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Neural Cell Adhesion Molecule as a Regulator of Cell-Cell Interactions
1990Progress in the investigation of cell-cell interactions in tissue formation has been particularly rapid in recent years (for review see Rutishauser and Jessell, 1988). A fundamental hypothesis throughout this work has been that these interactions reflect specific molecular complementarity mediated by distinct components at the cell surface. In addition,
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The Neural Cell Adhesion Molecule NCAM and Lipid Rafts
2009Detergent-resistant membrane microdomains, the so-called lipid rafts, are involved in a wide array of cellular processes including membrane trafficking and intracellular signalling. In connection with the increased interest in lipid rafts, these structures have been reported in a number of studies to be of critical importance for signalling processes ...
Dorte Kornerup Ditlevsen +1 more
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Regulation of neural cell adhesion molecule sialylation state
International Journal of Biochemistry, 1991The neural cell adhesion molecule (NCAM) is a complex of three immunologically-related membrane polypeptides of 180, 140 and 120 kDa molecular weight (Hirn et al., 1983; Choung and Edelman, 1984; Sheehan et al., 1986). These isoforms are primary translation products which arise through the alternate splicing of a single gene located on human chromosome
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Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM
Nature, 1994A. Lüthi +4 more
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Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms
2009Neural cell adhesion molecule (NCAM) was initially characterized in cells of the nervous system, where its role in various neural processes is well established. However, NCAM is also expressed in a wide variety of non-neuronal cell types, where its function has been remained largely elusive. Importantly, the expression of NCAM appears to be deregulated
Silvia Zecchini, Ugo Cavallaro
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Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily
1996Publisher Summary This chapter reviews some of the structural features of the immunoglobulin (Ig)-CAMS. It describes some of their interactions with other molecules of the same and different types and discusses some aspects of the intracellular signalling mediated through this binding. One of the distinguishing characteristics of immunoglobins and Ig-
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Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule
2009Polysialic acid is a unique glycan polymer composed of long chains of α2, 8-linked sialic acid residues; it is found on a small subset of mammalian proteins. The neural cell adhesion molecule, NCAM, is the most abundant polysialylated protein in mammalian cells.
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