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D609 inhibits the proliferation of neural progenitor cells
NeuroReport, 2010We examined the effect of tricyclodecan-9-yl-xanthogenate (D609), a phosphatidylcholine-specific phospholipase C inhibitor, on the proliferation of adult neural progenitor cells in vitro. D609 (100 microM) decreased the proliferation of neural progenitor cells as measured by the proliferation assay, bromodeoxyuridine incorporation, and cell counting ...
Haviryaji S G, Kalluri +1 more
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Psychopharmacology of latent inhibition: a neural network approach
Behavioural Pharmacology, 1998A neural network model of classical conditioning is applied to the description of some aspects of the psychopharmacology of latent inhibition (LI). According to the model, LI is manifested because preexposure of the conditioned stimulus (CS) reduces Novelty, defined as proportional to the sum of the mismatches between predicted and observed events ...
N A, Schmajuk, C V, Buhusi, J A, Gray
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Neural Antigens and Induction of Myelination Inhibition Factor
The Journal of Immunology, 1975Abstract Rabbits were sensitized or immunized with a variety of central nervous system antigens, including bovine spinal cord, bovine, monkey, human, guinea pig, rabbit, and rat S myelin basic proteins, and a polypeptide derived from guinea pig basic protein.
F J, Seil, M W, Kies, M, Bacon
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Impulsivity and neural correlates of response inhibition in schizophrenia
Psychological Medicine, 2010BackgroundThe clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet examined the relationship between ...
A, Kaladjian +4 more
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Inhibition in Neural Systems of the Cerebral Cortex
1968Publisher Summary Recent microelectrode research has revealed cortical neurons that react selectively and characteristically to different repetitive stimuli. Observing the latencies of responses of different cortical neurons, one may conclude that their recruiting in the reaction is not a simultaneous process.
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The Neural Mechanisms of Behavioral Inhibition
2018Unfamiliar people, places, and objects often elicit wariness and distress in behaviorally inhibited infants. As behaviorally inhibited infants mature through childhood and become adolescents, peer-based social situations become the driving source of this wariness.
Johanna M. Jarcho, Amanda E. Guyer
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Neural mechanisms of response inhibition
Current Opinion in Behavioral Sciences, 2015Response inhibition is the most basic form of behavioral control, which can occur either proactively to anticipate known task requirements, or reactively in response to sudden changes in the environment. This review will highlight some of the recent progress that has been made in understanding the mechanisms of response inhibition.
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Parasympathetic inhibition of sympathetic neural activity to the pancreas
American Journal of Physiology-Endocrinology and Metabolism, 2001The present study tested the hypothesis that activation of the parasympathetic nervous system could attenuate sympathetic activation to the pancreas. To test this hypothesis, we measured pancreatic norepinephrine (NE) spillover (PNESO) in anesthetized dogs during bilateral thoracic sympathetic nerve stimulation (SNS; 8 Hz, 1 ms, 10 mA, 10 min) with and
L, Benthem +2 more
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Inhibition of in vivo Neural Vasoconstriction by Exogenous Catecholamines
Blood Vessels, 2008Intraarterial infusions of norepinephrine and dopamine markedly attenuated the mesenteric vasoconstrictor response to periarterial nerve stimulation in anesthetized cats, but did not attenuate the response to intravenous noiepinephrine. The degree of attenuation was independent of stimulation voltage, but inversely related to frequency. The results are
K M, Sanders, G, Ross
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Neural Networks to Calculate CDK2 Inhibition
Cyclin-dependent kinase 2 (CDK2) participates in eukaryotic cell-cycle progression. CDK2's role in the cell cycle indicates that this enzyme is a target for anticancer drugs. Available high-resolution X-ray crystallographic structures and binding affinity data made it possible to construct machine learning models to predict affinity based on atomic ...openaire +2 more sources