Results 61 to 70 of about 815,001 (281)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A method for protecting neural networks from computer backdoor attacks based on the trigger identification

open access: yesНаучно-технический вестник информационных технологий, механики и оптики
Modern technologies for the development and operation of neural networks are vulnerable to computer attacks with the introduction of software backdoors. Program backdoors can remain hidden indefinitely until activated by input of modified data containing
A. B. Menisov   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

An original framework for understanding human actions and body language by using deep neural networks [PDF]

open access: yes, 2020
The evolution of both fields of Computer Vision (CV) and Artificial Neural Networks (ANNs) has allowed the development of efficient automatic systems for the analysis of people's behaviour. By studying hand movements it is possible to recognize gestures,
MASSARONI, CRISTIANO
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Neural Programming by Example

open access: yes, 2017
Programming by Example (PBE) targets at automatically inferring a computer program for accomplishing a certain task from sample input and output. In this paper, we propose a deep neural networks (DNN) based PBE model called Neural Programming by Example (
Shu, Chengxun, Zhang, Hongyu
core   +1 more source

Computing with dynamic attractors in neural networks [PDF]

open access: yesBiosystems, 1995
In this paper we report on some new architectures for neural computation, motivated in part by biological considerations. One of our goals is to demonstrate that it is just as easy for a neural net to compute with arbitrary attractors--oscillatory or chaotic--as with the more usual asymptotically stable fixed points.
Hirsch, MW, Baird, B
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Bipolar Morphological Neural Networks: Gate-Efficient Architecture for Computer Vision

open access: yesIEEE Access, 2021
The priority of building hardware-oriented neural network models is growing steadily. The target goals for their development are the performance and energy efficiency of promising hardware-software solutions.
Elena E. Limonova   +3 more
doaj   +1 more source

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