Graph Pseudotime Analysis and Neural Stochastic Differential Equations for Analyzing Retinal Degeneration Dynamics and Beyond [PDF]
Understanding disease progression at the molecular pathway level usually requires capturing both structural dependencies between pathways and the temporal dynamics of disease evolution. In this work, we solve the former challenge by developing a biologically informed graph-forming method to efficiently construct pathway graphs for subjects from our ...
arxiv
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox+3 more
wiley +1 more source
A POSSIBLE EXPLANATION FOR NEURODEGENERATIVE DISEASE
This review proposes an explanation for the pathogenesis of those neurodegenerative diseases which result in dementia and the resulting diversity of their disease phenotypes.
Richard A. Armstrong
doaj
Neural pathways of attitudes toward foreign languages predict academic performance. [PDF]
Lu D, Wang X, Wei Y, Cui Y, Wang Y.
europepmc +1 more source
Spatial Learning Activates Neural Cell Adhesion Molecule Polysialylation in a Corticohippocampal Pathway Within the Medial Temporal Lobe [PDF]
Alan W. O'Connell+7 more
openalex +1 more source
Sparsity is All You Need: Rethinking Biological Pathway-Informed Approaches in Deep Learning [PDF]
Biologically-informed neural networks typically leverage pathway annotations to enhance performance in biomedical applications. We hypothesized that the benefits of pathway integration does not arise from its biological relevance, but rather from the sparsity it introduces.
arxiv
In this randomized clinical trial conducted among 142 community‐dwelling older adults at high risk for falls over 12 months, a Dalcroze Eurhythmics exercise intervention (once weekly, group‐based) improved a variety of physical and cognitive/executive function outcomes compared with a multicomponent exercise intervention (twice weekly, group‐ and home ...
Mélany Hars+7 more
wiley +1 more source
Vital dye labelling of Xenopus laevis trunk neural crest reveals multipotency and novel pathways of migration [PDF]
Although the Xenopus embryo has served as an important model system for both molecular and cellular studies of vertebrate development, comparatively little is known about its neural crest.
Bronner-Fraser, Marianne+2 more
core
Holistic structure of neural pathways underlies brain perceptual rivalry: Physical mechanism of auditory stream segregation [PDF]
Brain perceptual rivalry, exemplified by auditory stream segregation of competing tones (A_, B__, ABA_), serves as a core mechanism of brain perception formation. While increasingly recognized as determining by neural connections rather than specific neural groups, the mechanism of brain perception remains uncertain. We demonstrate that auditory stream
arxiv
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim+3 more
wiley +1 more source