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Science, 2017
Neurodevelopment The development of the neural tube is regulated by a pair of morphogens acting in opposing gradients. The mature neural tube is built from a variety of different cell types organized in a consistent dorsal-ventral pattern. Zagorski et al. asked how this pattern is defined in a reproducible way from individual to individual.
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Neurodevelopment The development of the neural tube is regulated by a pair of morphogens acting in opposing gradients. The mature neural tube is built from a variety of different cell types organized in a consistent dorsal-ventral pattern. Zagorski et al. asked how this pattern is defined in a reproducible way from individual to individual.
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The Pattern of Neural Tube Defects Created by Secondary Reopening of the Neural Tube
Journal of Child Neurology, 1990The usual location of human neural tube defects at the rostral or caudal end of the primary neural tube suggests they are caused by failure of closure of the neural tube. In this study, neural tube defects were created by surgical reopening of the neural tube of 3-day-old duck embryos in one of three sites: the forebrain, cervicothoracic region, or ...
L R, Campbell, G S, Sohal
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Genetics of neural tube defects
Seminars in Pediatric Neurology, 2001Neural tube defects (NTDs) are common congenital malformations that occur when the embryonic neural tube fails to close properly during early development. Although multifactorial in origin, NTDs appear to have a strong genetic component. Mouse NTD mutants provide useful models for the study of candidate genes involved in neural tube development and ...
J, Gelineau-van Waes, R H, Finnell
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Patterning the protochordate neural tube
Current Opinion in Neurobiology, 2001The complex vertebrate nervous system has evolved from a simpler nervous system such as that seen in present-day protochordates. Through a recent accumulation of gene-expression data, together with fine anatomical studies, we are now able to identify both how the neural tube was patterned when it first evolved and what is truly novel in the vertebrate ...
H, Wada, N, Satoh
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Immunohistochemistry of Medulloepithelioma and Neural Tube
Fetal and Pediatric Pathology, 1997Immunohistochemistry profiles of medulloepithelioma (from two 2 1/2-year-old girls who had cerebral medulloepitheliomas and a 35-week postconceptional female infant with congenital posterior fossa tumor) and neural tube are compared. Microscopically, the tumors contained a medulloepitheliomatous component, manifested as tubular epithelial structures ...
M, Khoddami, L E, Becker
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2015
Let us begin our discussion of the neural tube and its regional differentiation by looking at some historic pictures, one from His (1893b), and three from Karl Von Kupffer (1906).
Rudolf Nieuwenhuys, Luis Puelles
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Let us begin our discussion of the neural tube and its regional differentiation by looking at some historic pictures, one from His (1893b), and three from Karl Von Kupffer (1906).
Rudolf Nieuwenhuys, Luis Puelles
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Sex, neural tube defects, and multisite closure of the human neural tube
American Journal of Medical Genetics, 1995AbstractWhile neural tube defects (NTD) overall have a female sex bias, this does not apply to all sites along the neuraxis. The findings regarding sex and NTD in a series of midtrimester fetuses are reviewed, and then analysed in terms of the recent hypothesis that during embryogenesis of the human neural tube there are multiple closure sites, rather ...
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The prevention of neural tube defects
Current Opinion in Obstetrics and Gynaecology, 1998The prevention of neural tube defects is a complex problem. The genetic associations may ultimately allow the prepregnancy identification of women at high risk of a neural tube defect. Education of both the public and healthcare providers has been shown to increase awareness, but the majority of women do not take folic acid before and in the early part
S, Daly, J M, Scott
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Neural tube defects in the Sikhs
American Journal of Medical Genetics, 1983AbstractBackground information on the incidence of neural tube defects (NTD) in Sikhs in India and elsewhere is given. The incidence of NTD in the Sikh population of British Columbia is estimated for 4 years and found to be 2.86 per 1,000 births. The overall rate for NTD in all B.C. births for these same years is 1.26 per 1,000 births.
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Organoids as a new model system to study neural tube defects
FASEB Journal, 2021Yufang Zheng, Richard Finnell
exaly