Results 71 to 80 of about 12,549 (219)

The Comparison of Gabapentin and Amitriptilin Effectivity as Pain Therapy in Herniated Nucleus Pulposus [PDF]

, 2015
Herniated nucleus pulposus (HNP) is one of peripheral neuropathic pain. Although concensus guidelines for the treatment of neuropathic pain are based on the results of the RCT studies, there are still gaps in the literatures.
Cahyaningsih, I. (Indriastuti), Handayani, R. (Rina), Setyaningsih, S. (Setyaningsih)   +2 more
core  

Predictors for persistent neuropathic pain. A Delphi survey [PDF]

, 2011
Chronic neuropathic pain has a major effect on quality of life. In order to prevent neuropathic pain from becoming chronic and improve neuropathic pain care, it is important to identify predictors associated with the persistence of neuropathic pain ...
Boogaard, S., Faber, C.G., Heijmans, M.W., Loer, S.A., Patijn, J., Perez, R.S.G.M., Peters, M.L., Vet, H.C.W. de, Zuurmond, W.W.A.   +8 more
core   +6 more sources

Non‐Invasive Brain Stimulation in Chronic Pain: Current Evidence, Network Perspectives and Paths to Personalization

Sensory Neuroscience, Volume 2, Issue 1, March 2026.
Chronic pain reflects maladaptive network interactions across sensory, salience/affective, and descending modulatory pathways. We review evidence for non‐invasive brain stimulation—rTMS, tES, and low‐intensity focused ultrasound—highlighting modest, variable, and often short‐lived analgesic effects under conventional protocols.
Fabian Broecker, Sven Vanneste
wiley   +1 more source

Gabapentin enacarbil extended release for the treatment of postherpetic neuralgia in adults

Therapeutics and Clinical Risk Management, 2013
Ben M Thomas,1 Paul Farquhar-Smith2 1Chelsea Westminster Hospital, London, UK; 2Department of Anaesthetics, The Royal Marsden NHS Foundation Trust, London, UK Abstract: The development of biomedical technology is allowing refinement of drug therapies in ...
Thomas BM, Farquhar-Smith P
doaj  

Impaired Modulation of Pain in Patients with Postherpetic Neuralgia

Pain Research and Management, 2014
BACKGROUND: The efficiency of inhibitory pain descending pathways (evaluated using conditioned pain modulation [CPM]) has not been studied in postherpetic neuralgia (PHN).
Gisèle Pickering, Bruno Pereira, Elodie Dufour, Sylvie Soule, Claude Dubray   +4 more
doaj   +1 more source

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]

, 2013
BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J, Brown, Stephen, Fisher, Martin, Larbalestier, Nicholas, Moyle, Graeme, Orkin, Chloe, Schifitto, Giovanni, Simpson, David M, Tobias, Jeffrey K, Vanhove, Geertrui F   +9 more
core   +1 more source

Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster, Noy Midler, Ori Shine, Dekel Rosenfeld   +3 more
wiley   +1 more source

Neuralgias of the Trigeminal Nerve

Pain Research and Management, 2000
Practitioners are often presented with patients who complain bitterly of facial pain. The trigeminal nerve is involved in four conditions that are sometimes mixed up.
Allan S Gordon
doaj   +1 more source

Vöötohatis [PDF]

, 2017
Herpesvaricellae-zoster virus (VZV) on alfaherpesviiruste hulka kuuluv kaheahelaline DNA-viirus, mis põhjustab inimestel primaarinfektsioonina tuulerõugeid (varicella) ja sekundaarse infektsioonina vöötohatist (herpes zoster).
Puis, Liis
core   +2 more sources

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source