Results 91 to 100 of about 10,995 (256)

Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence

open access: yesBMC Microbiology, 2010
Background Sialic acid has been shown to be a major virulence determinant in the pathogenesis of otitis media caused by the bacterium Haemophilus influenzae.
Moxon Richard   +7 more
doaj   +1 more source

Label‐Free and Microplate‐Based Dissection of Glycan‐Virus Interactions Using Polymer‐Tethered Glyconanoparticles

open access: yesSmall Methods, Volume 9, Issue 8, August 20, 2025.
This work demonstrates the use of polymer‐tethered glycosylated gold nanoparticles for the label‐free evaluation of influenza virus binding in a simple microplate. Sialylated linear and branched glycans are integrated using a modular capture and assembly process. The microplate‐based assays are shown to correlate with biolayer interferometry and can be
Sarah‐Jane Richards   +11 more
wiley   +1 more source

Gut Microbiota Composition and Modulation in Developmental and Epileptic Encephalopathies

open access: yesEuropean Journal of Neuroscience, Volume 62, Issue 4, August 2025.
Clinical studies link gut microbiota (GM) composition to adrenocorticotropic hormone (ACTH) treatment response. In infantile epileptic spasms syndrome (IESS) mouse models, GM modulation via antibiotics, ketogenic diet (KD), fecal transplantation, or probiotics reduced epileptic spasms, while in Dravet syndrome (DS) models, the KD showed no anti‐seizure
Takwa Ammar   +3 more
wiley   +1 more source

Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax [PDF]

open access: yes, 2015
Sialidases and trans-sialidases play important roles in the life cycles of various microorganisms. These enzymes can serve nutritional purposes, act as virulence factors or mediate cellular interactions (cell evasion and invasion).
Ameloot, Paul   +5 more
core   +1 more source

Safety of lacto‐N‐tetraose (LNT) produced by a derivative strain (Escherichia coli K‐12 MG1655 INB_LNT_01) of E. coli K‐12 MG1655 (ATCC 700926) as a novel food pursuant to Regulation (EU) 2015/2283

open access: yesEFSA Journal, Volume 23, Issue 8, August 2025.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on lacto‐N‐tetraose (LNT) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) LNT, but it also contains lacto‐N ...
EFSA Panel on Nutrition   +30 more
wiley   +1 more source

Physico-chemical characterization of a natural agglutinin from the hemolymph of a millipede Thyropygus descriptus [PDF]

open access: yesInvertebrate Survival Journal, 2014
Natural hemagglutinins with specific affinity for the glycocalyx of rabbit erythrocytes is identified in the hemolymph of the millipedes, Thyropygus descriptus, Xenobolus acuticonus, Arthrosphaera disticta and A. craspedota.
SrMR Basil-Rose   +2 more
doaj   +2 more sources

A Nomogram for Early Diagnosis of Community-Acquired Pneumonia Based on Bronchoalveolar Lavage Fluid Metabolomics

open access: yesInfection and Drug Resistance, 2023
Siqin Chen,1,* Minhong Su,2,* Wei Lei,1,* Zhida Wu,1 Shuhong Wu,1 Jing Liu,1 Xiaoyan Huang,1 Guiyang Chen,1 Qian Zhang,1 Hua Zhong,1 Fu Rong,1 Xi Li,1 Qiang Xiao1 1Pulmonary and Critical Care Medicine, Shunde Hospital, Southern Medical ...
Chen S   +12 more
doaj  

Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen.

open access: yesPLoS Pathogens, 2019
Typhoid toxin is a virulence factor for Salmonella Typhi and Paratyphi, the cause of typhoid fever in humans. This toxin has a unique architecture in that its pentameric B subunit, made of PltB, is linked to two enzymatic A subunits, the ADP ribosyl ...
Shu-Jung Chang   +3 more
doaj   +1 more source

Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. [PDF]

open access: yes, 2011
Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively.
Elenore S. Bogoch, Samuel Bogoch
core   +2 more sources

N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses

open access: yesCell Reports, 2019
Summary: A species barrier for the influenza A virus is the differential expression of sialic acid, which can either be α2,3-linked for avians or α2,6-linked for human viruses.
Frederik Broszeit   +19 more
doaj   +1 more source

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