Results 31 to 40 of about 380 (174)

Retroviral b‐Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation

Journal of Extracellular Biology, Volume 2, Issue 7, July 2023., 2023
Abstract HTLV‐I‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive, neuroinflammatory demyelinating condition of the spinal cord. We have previously shown that aberrant expression and activity of immune checkpoint (ICP) molecules such as PD‐1 and PD‐L1/PD‐L2, negatively associates with the cytolytic potential of T ...
Julie Joseph, Thomas A. Premeaux, Daniel O. Pinto, Abhishek Rao, Shrobona Guha, Amanda R. Panfil, Alison J. Carey, Lishomwa C. Ndhlovu, Elke S. Bergmann‐Leitner, Pooja Jain   +9 more
wiley   +1 more source

Molecular Mechanism of MLC 901 in Acute Ischemic Stroke: A Review. [PDF]

Stroke Res Treat
Ischemic stroke is the leading cause of stroke all around the world. Ischemic stroke can cause severe and irreversible damage to the brain. Brain neuroprotection is a promising treatment strategy. Moleac (MLC) 901, a traditional Chinese medicine, is one alternative adjunctive therapy that enhances neuroprotection.
Hunaifi I, Bintang AK, Tammasse J, Wahid I, Hatta M, Islam AA, Zainuddin AA, Sugianto P.   +7 more
europepmc   +2 more sources

Towards nanomedicines for neuroAIDS [PDF]

Reviews in Medical Virology, 2014
SUMMARYAlthough highly active antiretroviral therapy (HAART) has resulted in remarkable decline in the morbidity and mortality in AIDS patients, controlling HIV infections still remain a global health priority. HIV access to the CNS serves as the natural viral preserve because most antiretroviral (ARV) drugs possess inadequate or zero delivery across ...
Vidya, Sagar, Sudheesh, Pilakka-Kanthikeel, Ravi, Pottathil, Shailendra K, Saxena, Madhavan, Nair   +4 more
openaire   +2 more sources

Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route

Journal of Nanotechnology, Volume 2023, Issue 1, 2023., 2023
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid‐induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid carriers (NLCs) have emerged as a promising delivery carrier ...
Alok Kumar Mahor, Prem Prakash Singh, Rishikesh Gupta, Peeyush Bhardwaj, Priyanka Rathore, Ankita Kishore, Rohit Goyal, Neeraj Sharma, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal, Nasrullah Jan   +11 more
wiley   +1 more source

Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques

Journal of Leukocyte Biology, Volume 112, Issue 5, Page 969-981, November 2022., 2022
Graphical Abstract ScRNA‐seq of rhesus monkey microglia reveals clusters of cells in activated states in the setting of SIV infection, which is primarily reversed by suppressing viremia with combination antiretroviral therapy. Abstract Microglia and macrophages are essential for homeostatic maintenance and innate immune response in the brain.
Andrew J. Trease, Meng Niu, Brenda Morsey, Chittibabu Guda, Siddappa N. Byrareddy, Shilpa Buch, Howard S. Fox   +6 more
wiley   +1 more source

The NeuroAiD Safe Treatment (NeST) Registry: a protocol [PDF]

BMJ Open, 2015
N Venketasubramanian, Narayanaswamy Venketasubramanian, Ramesh Kumar   +2 more
exaly   +2 more sources

Animal models for studies of HIV‐1 brain reservoirs

Journal of Leukocyte Biology, Volume 112, Issue 5, Page 1285-1295, November 2022., 2022
Graphical Abstract Review on recent rodent models that contain both human myeloid and T cells for future therapeutics and viral elimination investigations in CNS. Abstract The HIV‐1 often evades a robust antiretroviral‐mediated immune response, leading to persistent infection within anatomically privileged sites including the CNS.
Emiko Waight, Chen Zhang, Saumi Mathews, Bhavesh D. Kevadiya, K. C. Kent Lloyd, Howard E. Gendelman, Santhi Gorantla, Larisa Y. Poluektova, Prasanta K. Dash   +8 more
wiley   +1 more source

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

Annals of Neurology, Volume 92, Issue 4, Page 532-544, October 2022., 2022
Objective Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size and replication competent nature of the central nervous system (CNS) reservoir is unclear.
Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo, Gemma S. Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J. Gartner, Trisha A. Jenkins, Paul R. Gorry, Bruce J. Brew, Sharon R. Lewin, Jacob D. Estes, Michael Roche, Melissa J. Churchill   +18 more
wiley   +1 more source

NeuroAIDS: An Evolving Epidemic [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2009
Over 60,000 Canadians are infected with human immunodeficiency virus (HIV). Greater than 50% of these individuals will develop a neurological disorder despite the availability of highly active antiretroviral therapy. HIV causes nervous system disease at all stages of infection with adverse effects on quality of life, adherence to medications ...
Christopher, Power, Lysa, Boissé, Sean, Rourke, M John, Gill   +3 more
openaire   +2 more sources

Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation

Immunological Reviews, Volume 311, Issue 1, Page 224-233, October 2022., 2022
Abstract Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1 (SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that functions not only in intercellular communication, but also in the extracellular matrix (ECM).
Ashley Yim, Christian Smith, Amanda M. Brown   +2 more
wiley   +1 more source