Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. [PDF]
, 2020 BackgroundPoor socioeconomic and health-related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals.
Armstrong, Gregory T +11 more
core +2 more sources
Psychosomatic Medicine, 2010 Objectives: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have been hampered by ...
Patrick J. Smith +7 more
semanticscholar +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Can the g Factor Play a Role in Artificial General Intelligence Research? [PDF]
, 2018 In recent years, a trend in AI research has started to pursue human-level, general artificial intelli-gence (AGI). Although the AGI framework is characterised by different viewpoints on what intelligence is and how to implement it in artificial systems ...
Frixione, Marcello, Serpico, Davide
core +1 more source
Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. [PDF]
, 2019 Purpose of reviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.Recent ...
Blennow, Kaj +6 more
core +2 more sources
Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Brain MRI findings in severe COVID-19 patients: a meta-analysis
Frontiers in Neurology, 2023 IntroductionNeurocognitive symptoms and dysfunction of various severities have become increasingly recognized as potential consequences of SARS-CoV-2 infection.
Montek S. Boparai +5 more
doaj +1 more source
Cognitive dysfunction improves in systemic lupus erythematosus: Results of a 10 years prospective study [PDF]
, 2018 Objective Cognitive impairment (CI) has been described in 3–80% of Systemic lupus erythematosus (SLE) patients but only short-term studies evaluated its over-time changes, suggesting that CI is usually a stable finding. We aimed at evaluating the changes
Alessandri, Cristiano +9 more
core +2 more sources
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder [PDF]
, 2023 Fuhai Bai +8 more
openalex +1 more source