Results 151 to 160 of about 241,511 (306)

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease [PDF]

arXiv, 2017
Oxidative stress is a pathological hallmark of neurodegenerative tauopathic disorders such as Alzheimer's disease and Parkinson's disease-related dementia, which are characterized by altered forms of the microtubule-associated protein (MAP) tau. MAP tau is a key protein in stabilizing the microtubule architecture that regulates neuron morphology and ...
arxiv  

Neurodegenerative diseases and transglutaminase [PDF]

, 1996
L. Lóránd
openalex   +1 more source

Neurodegenerative Disease Tauopathies

Annual Review of Pathology: Mechanisms of Disease
Tauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and ...
Creekmore, Benjamin C., Watanabe, Ryohei, Lee, Edward B.   +2 more
openaire   +2 more sources

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

Mitochondria and Free Radicals in Neurodegenerative Diseases [PDF]

, 1998
Larry W. Oberley
openalex   +1 more source

Molecular dynamics studies on the NMR and X-ray structures of rabbit prion protein wild-type and mutants

, 2013
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep, goats, mice, humans, chimpanzees, hamsters, cattle, elks, deer, minks, cats, chicken, pigs, turtles, etc ...
Barlow, Baron, Barry, Barry, Barry, Bastian, Bencsik, Bendheim, Bett, Biswas, Bitel, Bjorndahl, Bockman, Bode, Brun, Caughey, Chianini, Cho, Chou, Chou, Chou, Chou, Chou, Chou, Chou, Christen, Christen, Christen, Christen, Cong, Courageot, Damberger, Di Martino, Dong, Dupiereux, Farquhar, Fernandez-Funez, Fernandez-Funez, Fernandez-Funez, Fernández-Borges, Friedman-Levi, Gabizon, Gabizon, Gao, Garrec, Garssen, Gerber, Gilch, Golanska, Gossert, Groschup, Groschup, Groschup, Guiroy, Handisurya, Hanoux, Hashimoto, Hay, Huang, Ikegami, Ishiguro, Ishikawa, Jackman, Jiapu Zhang, Julien, Kabsch, Kascsak, Kascsak, Kelker, Khan, Kim, Kirby, Kirkwood, Kitamoto, Kocisko, Komar, Korth, Laude, Lawson, Li, Li, Loftus, Lopez, Lührs, Ma, Madec, Mays, Meli, Merz, Miller, Nisbet, Oboznaya, Onodera, Polymenidou, Pérez, Riek, Robakis, Roberts, Rossetti, Sachsamanoglou, Sakudo, Schmerr, Senator, Shin, Shinagawa, Sigurdson, Sigurdson, Sigurdson, Stanker, Sweeting, Takahashi, Takahashi, Takekida, Tang, Timmes, Vidal, Vilette, Vol'pina, Vorberg, Wade, Wang, Wen, Wen, Wiley, Xi, Xiao, Yokoyama, Yokoyama, Yost, Yuanli Zhang, Zahn, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zocche Soprana   +142 more
core   +1 more source

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

Pathways to Primary Neurodegenerative Disease [PDF]

, 1999
John Hardy
openalex   +1 more source

Nutrition and cerebral neurodegenerative diseases [PDF]

, 2016
Tato bakalářská práce má formu rešerše a jejím tématem je studium vlivu výživy na rozvoj neurodegenerativních onemocnění. Práce je rozdělena na čtyři části.
Šálková, Michaela
core