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Impact of Peripheral Inflammation on Blood-Brain Barrier Dysfunction and Its Role in Neurodegenerative Diseases. [PDF]
Int J Mol SciBeltran-Velasco AI, Clemente-Suárez VJ.
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Radiologic Clinics of North America, 2008
This article outlines the changes seen using various imaging modalities in the normally aging brain and then discusses in detail the changes seen with various pathologic conditions. Entities discussed include primary degenerative dementias, extrapyramidal system diseases, and vascular dementias.
Gallucci M. +3 more
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This article outlines the changes seen using various imaging modalities in the normally aging brain and then discusses in detail the changes seen with various pathologic conditions. Entities discussed include primary degenerative dementias, extrapyramidal system diseases, and vascular dementias.
Gallucci M. +3 more
openaire +3 more sources
SUMOylation in Neurodegenerative Diseases
Gerontology, 2019Posttranslational modifications are ubiquitous regulators of cellular processes. The regulatory role of SUMOylation, the attachment of a small ubiquitin-related modifier to a target protein, has been implicated in fundamental processes like cell division, DNA damage repair, mitochondrial homeostasis, and stress responses.
Princz, Andrea, Tavernarakis, Nektarios
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Microbiota and neurodegenerative diseases
Current Opinion in Neurology, 2017Purpose of review Despite the extensive research carried out in the past decades, the current pathophysiological notions of neurodegenerative disease as well as effective treatments to reduce their progression are largely unknown. Alterations of the human microbiota, the plethora of different microscopic organisms that our body
Marizzoni, Moira +3 more
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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Neuroprotection and Neurodegenerative Disease
Journal of Clinical Neuroscience, 2002This paper will focus on commonalities in the aetiology and pathology in five areas of neurological disease with illustrative examples of therapy. Possibilities of multimodal and neuroprotective therapies in human disease, employing currently available drugs and showing evidence of neuroprotective potential in animal models, are discussed.
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