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Endocannabinoids and neurodegenerative diseases
Pharmacological Research, 2007The cannabinoid CB1 and CB2 receptors, the endogenous endocannabinoid (EC) ligands anandamide (AEA) and 2-arachidonylethanolamide, and the degradative enzymes fatty acid amide hydrolase (FAAH) and monoglyceride lipase (ML) are key elements of the EC system implicated in different physiological functions including cognition, motor activity and immune ...
MICALE, VINCENZO +2 more
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Optineurin in neurodegenerative diseases
Neuropathology, 2011Optineurin is a gene associated with normal tension glaucoma and primary open-angle glaucoma, one of the major causes of irreversible bilateral blindness. Recently, mutations in the gene encoding optineurin were found in patients with amyotrophic lateral sclerosis (ALS).
Yukio Fujita +5 more
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Ceruloplasmin in neurodegenerative diseases
Brain Research Reviews, 2005For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link
Vadim Vassiliev +2 more
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microRNAs and Neurodegenerative Diseases
2015microRNAs (miRNAs) are small, noncoding RNA molecules that through imperfect base-pairing with complementary sequences of target mRNA molecules, typically cleave target mRNA, causing subsequent degradation or translation inhibition. Although an increasing number of studies have identified misregulated miRNAs in the neurodegenerative diseases (NDDs ...
Qiu L., Tan E.K., Zeng L.
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Glucose, glycolysis, and neurodegenerative diseases
Journal of Cellular Physiology, 2020Prolonged survival of a typical postmitotic neuron hinges on a balance between multiple processes, among these are a sustenance of ATP production and protection against reactive oxygen species. In neuropathological conditions, mitochondrial defects often
B. Tang
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Glycosaminoglycans in Neurodegenerative Diseases
2021Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which are sulfated. GAGs are ubiquitously expressed on the cell surface, in the intracellular milieu and in the extracellular matrix of all animal cells.
Fuming Zhang +2 more
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Cannabinoids and Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets, 2009Although significant advances have taken place in recent years on our understanding of the molecular mechanisms of different neurodegenerative diseases, its translation into effective therapeutic treatments has not been as successful as could be expected.
Romero J, Orgado Jm
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Biomarkers for neurodegenerative diseases
Nature Network Boston, 2021O. Hansson
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Ceruloplasmin in neurodegenerative diseases
Biochemical Society Transactions, 2008Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J. Texel +2 more
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Meditation and neurodegenerative diseases
Annals of the New York Academy of Sciences, 2013Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients. With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time.
Daniela Monti +5 more
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