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Receptors in neurodegenerative diseases
Pharmaceutica Acta Helvetiae, 2000The ability of trophic factors to regulate developmental neuronal survival and adult nervous system plasticity suggests the use of these molecules to treat neurodegeneration associated with human diseases, such as Alzheimer's, Huntington's and Parkinson's disease, of amyotrophic lateral sclerosis and peripheral sensory neuropathies.
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Sumoylation in neurodegenerative diseases
Cellular and Molecular Life Sciences, 2012The yeast SUMO (small ubiquitin-like modifier) orthologue SMT3 was initially discovered in a genetic suppressors screen for the centromeric protein Mif2 (Meluh and Koshland in Mol Bio Cell 6:793-807, 1). Later, it turned out that the homologous mammalian proteins SUMO1 to SUMO4 are reversible protein modifiers that can form isopeptide bonds with lysine
Petranka Krumova, Jochen H. Weishaupt
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The Spread of Neurodegenerative Disease
New England Journal of Medicine, 2012Dementias such as Alzheimer's disease and frontotemporal dementia are thought to spread from one part of the brain to another. Two recent studies suggest that a protein-templating mechanism underlies the spread of disease in at least a subgroup of these dementias.
Tamas Revesz, John Hardy
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Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Molecular Neurobiology, 2021Lijun Dai +5 more
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The Hippocampus in Neurodegenerative Disease
2014AD is the commonest neurodegenerative disorder resulting ultimately in dementia, a stage during which there is a loss of previously acquired intellectual skill and independent occupational and social function. Neurodegenerative changes within the hippocampus and an extended neuronal network involving the medial temporal and medial parietal lobe result ...
Kuven Moodley, Dennis Chan
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Applications of machine learning to diagnosis and treatment of neurodegenerative diseases
Nature Reviews Neurology, 2020Monika A. Myszczynska +8 more
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Nature, 2006Michael T. Lin, M. Beal
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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Molecular Neurobiology, 2015Yuanyuan Tang, W. Le
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