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Neuroimaging Clinics of North America, 2001
This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well
H H, Goebel, J, Bohl, W, Müller-Forell
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This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well
H H, Goebel, J, Bohl, W, Müller-Forell
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Microbiota and neurodegenerative diseases
Current Opinion in Neurology, 2017Purpose of review Despite the extensive research carried out in the past decades, the current pathophysiological notions of neurodegenerative disease as well as effective treatments to reduce their progression are largely unknown. Alterations of the human microbiota, the plethora of different microscopic organisms that our body
Marizzoni, Moira +3 more
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SUMOylation in Neurodegenerative Diseases
Gerontology, 2019Posttranslational modifications are ubiquitous regulators of cellular processes. The regulatory role of SUMOylation, the attachment of a small ubiquitin-related modifier to a target protein, has been implicated in fundamental processes like cell division, DNA damage repair, mitochondrial homeostasis, and stress responses.
Princz, Andrea, Tavernarakis, Nektarios
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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Neuroprotection and Neurodegenerative Disease
Journal of Clinical Neuroscience, 2002This paper will focus on commonalities in the aetiology and pathology in five areas of neurological disease with illustrative examples of therapy. Possibilities of multimodal and neuroprotective therapies in human disease, employing currently available drugs and showing evidence of neuroprotective potential in animal models, are discussed.
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Apoptosis and its therapeutic implications in neurodegenerative diseases
Clinical anatomy (New York, N.Y. Print), 2021Neurodegenerative disorders are characterized by progressive loss of particular populations of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson disease, Alzheimer disease, Huntington disease ...
N. Erekat
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Optineurin in neurodegenerative diseases
Neuropathology, 2011Optineurin is a gene associated with normal tension glaucoma and primary open-angle glaucoma, one of the major causes of irreversible bilateral blindness. Recently, mutations in the gene encoding optineurin were found in patients with amyotrophic lateral sclerosis (ALS).
Yukio Fujita +5 more
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Endocannabinoids and neurodegenerative diseases
Pharmacological Research, 2007The cannabinoid CB1 and CB2 receptors, the endogenous endocannabinoid (EC) ligands anandamide (AEA) and 2-arachidonylethanolamide, and the degradative enzymes fatty acid amide hydrolase (FAAH) and monoglyceride lipase (ML) are key elements of the EC system implicated in different physiological functions including cognition, motor activity and immune ...
MICALE, VINCENZO +2 more
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microRNAs and Neurodegenerative Diseases
2015microRNAs (miRNAs) are small, noncoding RNA molecules that through imperfect base-pairing with complementary sequences of target mRNA molecules, typically cleave target mRNA, causing subsequent degradation or translation inhibition. Although an increasing number of studies have identified misregulated miRNAs in the neurodegenerative diseases (NDDs ...
Qiu L., Tan E.K., Zeng L.
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Ceruloplasmin in neurodegenerative diseases
Brain Research Reviews, 2005For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link
Vadim Vassiliev +2 more
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