Journal of Neurodevelopmental Disorders, 2017 Background Gamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABAA receptor positive allosteric modulator, is hypothesized to improve symptoms such as anxiety ...
Andrew Ligsay +12 more
doaj +1 more source
Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities. [PDF]
, 2013 Background: Neurofibromatosis type 1 (NF1) is a monogenic disorder associated with cognitive impairments. In order to understand how mutations in the NF1 gene impact brain structure it is essential to characterize in detail the brain structural ...
Castelo-Branco, M +3 more
core +1 more source
Journal of Neurodevelopmental Disorders, 2018 Background Sleep disturbance is common in children with neurodevelopmental disorders, with high rates identified in children with Smith-Magenis syndrome (SMS), Angelman syndrome (AS), autism spectrum disorder (ASD) and tuberous sclerosis complex (TSC ...
J. Trickett +3 more
doaj +1 more source
Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders
, 2018 The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M. +2 more
core +2 more sources
Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health. [PDF]
, 2019 Disruption of epigenetic regulation by environmental toxins is an emerging area of focus for understanding the latter's impact on human health. Polybrominated diphenyl ethers (PBDEs), one such group of toxins, are an environmentally pervasive class of ...
Poston, Robert G, Saha, Ramendra N
core +1 more source
Phenotypically independent profiles relevant to mental health are genetically correlated
Translational Psychiatry, 2021 Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders.
Daniel Roelfs +7 more
doaj +1 more source
Early symptomatic syndromes eliciting neurodevelopmental clinical examinations [PDF]
, 2013 No abstract ...
Fernell, Elisabeth +2 more
core +3 more sources
Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]
, 2020 BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard +10 more
core
Innovative approaches to the study of social phenotypes in neurodevelopmental disorders: an introduction to the research topic [PDF]
, 2013 R01 HD033470 - NICHD NIH ...
Plesa Skwerer, Daniela +1 more
core +2 more sources
Molecular Autism, 2022 Background Social attention differences, expressed through gaze patterns, have been documented in autism spectrum disorder (ASD), with subtle differences also reported among first-degree relatives, suggesting a shared genetic link.
Kritika Nayar +3 more
doaj +1 more source