Results 31 to 40 of about 159,005 (302)

Pain evaluation and management in neurodevelopmental conditions [PDF]

, 2021
Individuals with neurodevelopmental disorders are at higher risk for both acute and chronic pain. Further, excessive pain exposure in known to have adverse effects on neurodevelopment and neurobehavior outcomes.
Marlon L. Wong, Eva Widerstrom-Noga, Widerstrom-Noga, Eva, Wong, Marlon L.   +3 more
core   +1 more source

Prospective study of autism phenomenology and the behavioural phenotype of Phelan–McDermid syndrome: comparison to fragile X syndrome, Down syndrome and idiopathic autism spectrum disorder

Journal of Neurodevelopmental Disorders, 2017
Background The limited behavioural phenotype literature on Phelan–McDermid syndrome (PMS) indicates atypically high levels of activity, impulsivity and autism spectrum disorder (ASD) behaviours.
Caroline Richards, Laurie Powis, Jo Moss, Christopher Stinton, Lisa Nelson, Christopher Oliver   +5 more
doaj   +1 more source

CNVs in neurodevelopmental disorders

Oncotarget, 2015
Copy number variations (CNVs) consist of duplications or deletions of chromosomal regions ranging from a few hundred to more than a million bases in size, and are likely to play a role in phenotypic diversity and evolution. Recent advances in the identification and mapping of CNVs among normal individuals and in model systems, using bioinformatics and ...
Chun-Ting, Lee, William J, Freed, Deborah C, Mash   +2 more
openaire   +2 more sources

SYT1-Associated Neurodevelopmental Disorder: A Narrative Review [PDF]

, 2022
Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. SYT1, an identified synaptotagmin protein,
Christopher L. Anderson, Paul R. Carney, Anderson, Christopher L., Riggs, Edith, Carney, Paul R., Zaynab Shakkour, Edith Riggs, Shakkour, Zaynab   +7 more
core   +2 more sources

Learning steers the ontogeny of an efficient hunting sequence in zebrafish larvae

eLife, 2020
Goal-directed behaviors may be poorly coordinated in young animals but, with age and experience, behavior progressively adapts to efficiently exploit the animal’s ecological niche.
Konstantinos Lagogiannis, Giovanni Diana, Martin P Meyer   +2 more
doaj   +1 more source

Subjective Experience of Episodic Memory and Metacognition: A Neurodevelopmental Approach [PDF]

, 2013
Episodic retrieval is characterized by the subjective experience of remembering. This experience enables the co-ordination of memory retrieval processes and can be acted on metacognitively.
Katalin Pauly-Takacs, Francis eEustache, Bérengère Guillery-Girard, Katalin ePauly-Takacs, Souchay, C, Eustache, F, Francis Eustache, Wojcik, DZ, Pauly-Takacs, K, Celine eSouchay, Berengere eGuillery-Girard, Dominika Zofia Wojcik, Guillery-Girard, B, Céline Souchay   +13 more
core   +1 more source

Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding

Frontiers in Neuroscience, 2016
Fragile X premutation alleles have 55-200 CGG repeats in the 5' UTR of the FMR1 gene. Altered zinc (Zn) homeostasis has been reported in fibroblasts from > 60 y old premutation carriers, in which Zn supplementation significantly restored Zn-dependent ...
Eleonora eNapoli, Catherine eRoss-Inta, Gyu eSong, Sarah eWong, Randi eHagerman, Randi eHagerman, Louise eGane, Jennifer eSmilowitz, Flora eTassone, Flora eTassone, Cecilia eGiulivi, Cecilia eGiulivi   +11 more
doaj   +1 more source

Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases

Molecular Genetics & Genomic Medicine, 2019
Background The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation.
Dragana Protic, Elber Y. Aydin, Flora Tassone, Maria M. Tan, Randi J. Hagerman, Andrea Schneider   +5 more
doaj   +1 more source

Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

Antioxidants, 2020
Autism spectrum disorders (ASD) are a group of neurodevelopmental syndromes with both genetic and environmental origins. Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the ...
Luca Pangrazzi, Luigi Balasco, Yuri Bozzi   +2 more
doaj   +1 more source

Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS

Nature Communications, 2022
Nuclear depletion and cytoplasmic accumulation of splicing factor SFPQ are hallmarks of ALS. Here the authors demonstrate a relationship between loss of SFPQ and the emergence in neurites of intron-retaining mRNAs enriched in ALS models and tissues.
Richard Taylor, Fursham Hamid, Triona Fielding, Patricia M. Gordon, Megan Maloney, Eugene V. Makeyev, Corinne Houart   +6 more
doaj   +1 more source