Results 31 to 40 of about 1,509,615 (258)

Prospective study of autism phenomenology and the behavioural phenotype of Phelan–McDermid syndrome: comparison to fragile X syndrome, Down syndrome and idiopathic autism spectrum disorder

Journal of Neurodevelopmental Disorders, 2017
Background The limited behavioural phenotype literature on Phelan–McDermid syndrome (PMS) indicates atypically high levels of activity, impulsivity and autism spectrum disorder (ASD) behaviours.
Caroline Richards, Laurie Powis, Jo Moss, Christopher Stinton, Lisa Nelson, Christopher Oliver   +5 more
doaj   +1 more source

Early Neuro-Psychomotor Therapy Intervention for Theory of Mind and Emotion Recognition in Neurodevelopmental Disorders: A Pilot Study

, 2022
The aim of the present study is to explore the effect of early neuro-psychomotor therapy to improve theory of mind skills and emotion recognition in children with neurodevelopmental disorders.
Martucci, Melania, Donatella Valente, Nicoletta Giacchetti, Marco Tofani, Sogos, Carla, Giacchetti, Nicoletta, Galeoto, Giovanni, Giangiacomo, Elisa, Aceti, Franca, Valente, Donatella, Visaggi, Maria Castellano, Elisa Giangiacomo, Melania Martucci, Tofani, Marco, Giovanni Galeoto, Franca Aceti, Carla Sogos, Federica Giovannone, Giovannone, Federica, Maria Castellano Visaggi   +19 more
core   +1 more source

Learning steers the ontogeny of an efficient hunting sequence in zebrafish larvae

eLife, 2020
Goal-directed behaviors may be poorly coordinated in young animals but, with age and experience, behavior progressively adapts to efficiently exploit the animal’s ecological niche.
Konstantinos Lagogiannis, Giovanni Diana, Martin P Meyer   +2 more
doaj   +1 more source

Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding

Frontiers in Neuroscience, 2016
Fragile X premutation alleles have 55-200 CGG repeats in the 5' UTR of the FMR1 gene. Altered zinc (Zn) homeostasis has been reported in fibroblasts from > 60 y old premutation carriers, in which Zn supplementation significantly restored Zn-dependent ...
Eleonora eNapoli, Catherine eRoss-Inta, Gyu eSong, Sarah eWong, Randi eHagerman, Randi eHagerman, Louise eGane, Jennifer eSmilowitz, Flora eTassone, Flora eTassone, Cecilia eGiulivi, Cecilia eGiulivi   +11 more
doaj   +1 more source

Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases

Molecular Genetics & Genomic Medicine, 2019
Background The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation.
Dragana Protic, Elber Y. Aydin, Flora Tassone, Maria M. Tan, Randi J. Hagerman, Andrea Schneider   +5 more
doaj   +1 more source

Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

Antioxidants, 2020
Autism spectrum disorders (ASD) are a group of neurodevelopmental syndromes with both genetic and environmental origins. Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the ...
Luca Pangrazzi, Luigi Balasco, Yuri Bozzi   +2 more
doaj   +1 more source

Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS

Nature Communications, 2022
Nuclear depletion and cytoplasmic accumulation of splicing factor SFPQ are hallmarks of ALS. Here the authors demonstrate a relationship between loss of SFPQ and the emergence in neurites of intron-retaining mRNAs enriched in ALS models and tissues.
Richard Taylor, Fursham Hamid, Triona Fielding, Patricia M. Gordon, Megan Maloney, Eugene V. Makeyev, Corinne Houart   +6 more
doaj   +1 more source

Disaster in pregnancy: midwifery continuity positively impacts infant neurodevelopment, QF2011 study

BMC Pregnancy and Childbirth, 2018
Background Research shows that continuity of midwifery carer in pregnancy improves maternal and neonatal outcomes. This study examines whether midwifery group practice (MGP) care during pregnancy affects infant neurodevelopment at 6-months of age ...
Gabrielle Simcock, Sue Kildea, Sue Kruske, David P. Laplante, Guillaume Elgbeili, Suzanne King   +5 more
doaj   +1 more source

Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics

Scientific Reports, 2023
Research continues to identify genetic variation, environmental exposures, and their mixtures underlying different diseases and conditions. There is a need for screening methods to understand the molecular outcomes of such factors. Here, we investigate a
Abishek Arora, Martin Becker, Cátia Marques, Marika Oksanen, Danyang Li, Francesca Mastropasqua, Michelle Evelyn Watts, Manish Arora, Anna Falk, Carsten Oliver Daub, Ingela Lanekoff, Kristiina Tammimies   +11 more
doaj   +1 more source

A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome

Journal of Neurodevelopmental Disorders, 2017
Background Gamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABAA receptor positive allosteric modulator, is hypothesized to improve symptoms such as anxiety ...
Andrew Ligsay, Anke Van Dijck, Danh V. Nguyen, Reymundo Lozano, Yanjun Chen, Erika S. Bickel, David Hessl, Andrea Schneider, Kathleen Angkustsiri, Flora Tassone, Berten Ceulemans, R. Frank Kooy, Randi J. Hagerman   +12 more
doaj   +1 more source