Results 141 to 150 of about 205,939 (352)

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Duodenal neuroendocrine tumors: Somewhere between the pancreas and small bowel?

, 2019
Adriana C. Gamboa, Yuan Liu, Rachel Lee, Mohammad Y. Zaidi, Charles A. Staley, David A. Kooby, Joshua H. Winer, Mihir M. Shah, Maria C. Russell, Kenneth Cardona, Shishir K. Maithel   +10 more
openalex   +2 more sources

Necrosis and Angioinvasion Predict Adverse Outcome in Pancreatic Neuroendocrine Tumors After Curative Surgical Resection: Results of a Single‐Center Series [PDF]

, 2011
Resit Demir, Johann Pohl, Abbas Agaimy, Georgios Peros, Aristotelis Perrakis, Susanne Merkel, Werner Hohenberger, Peter Klein   +7 more
openalex   +1 more source

Rectal neuroendocrine tumor [PDF]

Digestive Endoscopy, 2014
Jian, Wu, Rajaventhan, Srirajaskanthan, John, Ramage   +2 more
openaire   +2 more sources

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells [PDF]

, 2018
Background: Tumorigenesis is driven by stem cell (SC) overpopulation. BecauseALDH is both a marker for SCs in many tissues and a key enzyme in retinoid acid (RA)signaling, we studied RA signaling in normal and malignant colonic SCs.Hypothesis: RA ...
Boman, Bruce M., Fields, Jeremy Z., Gupta, Anindita, Kowash, Ryan, Masters, Gabriel, Modarai, Shirin R., Opdenaker, Lynn M., Viswanathan, Vignesh, Zhang, Tao   +8 more
core   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

P1.12-23 DLL3 Is a Predictive Marker of Sensitivity to Adjuvant Chemotherapy for High-Grade Neuroendocrine Tumors [PDF]

, 2019
Hiroyasu Ogawa, Y Sakai, Wataru Nishio, Y Fujibayashi, Megumi Nishikubo, Yasuhiko Nishioka, Shinya Tane, Yoshitaka Kitamura, Tomoya Sudo, Yojiro Sakuma, Michio Yoshimura   +10 more
openalex   +1 more source

Clinical Implications of Ki‐67 Index, Grade and Hormonal Changes in Pancreatic Neuroendocrine Tumors: Insights Into Tumor Heterogeneity Based on Primary and Secondary Lesions

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Pancreatic neuroendocrine tumors (PanNETs) show heterogeneity, including temporal shifts in proliferation and hormone production; however, their clinical implications remain uncertain. Methods This retrospective study included 114 patients with metastatic or recurrent PanNETs at Kyushu University Hospital.
Masatoshi Murakami, Nao Fujimori, Kazuhide Matsumoto, Keijiro Ueda, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa   +9 more
wiley   +1 more source

Diagnostic Performance of Combined Conventional CT Imaging Features and Radiomics Signature in Differentiating Grade 1 Tumors from Higher-Grade Pancreatic Neuroendocrine Neoplasms [PDF]

Florent Tixier, Felipe Lopez‐Ramirez, Alejandra Blanco, Ammar A. Javed, Linda C. Chu, Ralph H. Hruban, Mohammad Yasrab, Daniel Fadaei Fouladi, Shahab Shayesteh, Saeed Ghandili, Elliot K. Fishman, Satomi Kawamoto   +11 more
openalex   +1 more source