Results 161 to 170 of about 99,950 (263)

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

open access: yesThe Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi   +8 more
wiley   +1 more source

Establishment of patient-derived xenografts for neuroendocrine tumors in the avian embryo model. [PDF]

open access: yesEndocr Relat Cancer
Kulathunga N   +20 more
europepmc   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

open access: yesPediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil   +2 more
wiley   +1 more source

Retrospective evaluation of palliative care consultation in critically ill adult and pediatric cancer subjects

open access: yesPediatric Investigation, EarlyView.
Children with cancer received more palliative care consultation before, but fewer during, critical illness compared with adults. This disparity suggests underuse of palliative care during pediatric critical care. ABSTRACT Importance Palliative care consultation is an essential component of comprehensive care for patients with cancer during critical ...
Conrad Krawiec, Neal Thomas
wiley   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

open access: yesPrecision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang   +7 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

open access: yesSensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa   +5 more
wiley   +1 more source

The lesser the better? A systematic review and meta-analysis of resection strategy in lung neuroendocrine tumors. [PDF]

open access: yesJ Neuroendocrinol
Aviel G   +9 more
europepmc   +1 more source

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