Results 151 to 160 of about 361,579 (250)

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Combined pancreatic grade 1 neuroendocrine tumour and ductal adenocarcinoma - MiNEN versus collision tumour: a rare surgical case report and diagnostic challenge. [PDF]

J Surg Case Rep
Alshadood N, Yasir SH, Aldarawsha AN, Yousif FH, Elazab MS, Hasan SA, Ammash H, Mahmood MN.   +7 more
europepmc   +1 more source

Tolerability of Adjuvant Nivolumab in Esophageal or Gastroesophageal Junction Cancer: A Real‐World Study

International Journal of Cancer, EarlyView.
ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt, Anniek Strijdhorst, Tamara Jessica Huizer, Esther Albertien Kleibeuker, Sarah Derks, Bianca Mostert, Hanneke van Laarhoven, Jacco Juri de Haan   +7 more
wiley   +1 more source

Deep learning for predicting pituitary neuroendocrine tumour lineage and high-risk subtypes from histology. [PDF]

NPJ Precis Oncol
Zhang A, Zhao F, Wang D, Ge C, Xu J, Tian X, Cheng L, Wang W, Du Z, Li A, Xiong J, Wang M, Wu H.   +12 more
europepmc   +1 more source

Germline Cancer Predisposition and De Novo Contributions in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group

International Journal of Cancer, EarlyView.
ABSTRACT Approximately 6%–8% of children and adolescents with rhabdomyosarcoma (RMS) have an underlying cancer predisposition disorder (CPD), which varies between embryonal and alveolar subtypes and other clinical characteristics. Identifying a CPD remains challenging, as traditional approaches rely on clinical features and family history. Additionally,
Taylor M. Luckie, Sarah Scollon, Yao Yu, Aniko Sabo, Tiffany Chambers, Olga Taylor, Logan G. Spector, Michael E. Scheurer, Douglas S. Hawkins, Rajkumar Venkatramani, Chad D. Huff, Sharon E. Plon, Philip J. Lupo   +12 more
wiley   +1 more source

Integrated pathology and interventional diagnostic approach to a metastatic grade 1 pancreatic neuroendocrine tumour: a clinical vignette of delayed diagnosis in a low-resource setting. [PDF]

Rep Pract Oncol Radiother
Babalola OT, Damitan SY.
europepmc   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Clinical Outcomes in Trans-sphenoidal Surgery for Pituitary Neuroendocrine Tumour in Sarawak General Hospital, Malaysia: Microscopic Versus Endoscopic Approach. [PDF]

Cureus
Ng PM, Wong AS, Tang IP, Abdullah JM.
europepmc   +1 more source

Association Between Interleukin‐6 Promoter Polymorphisms and Disease Susceptibility: A Review of Current Evidence

iLABMED, EarlyView.
IL‐6 SNPs contribute to the pathogenesis of diverse diseases by altering gene expression, and hold potential as biomarkers for disease risk assessment. ABSTRACT Interleukin 6 (IL‐6), a type of cytokine, plays a role in the onset, progression, and prognosis of various diseases.
Junyi Li, Yiling Xv, Qingfeng Ma, Wei Wang   +3 more
wiley   +1 more source

Pulmonary neuroendocrine tumour-associated ectopic Cushing's syndrome: diagnostic challenges and multidisciplinary management. [PDF]

Endocrinol Diabetes Metab Case Rep
Carrasco B RD, Juanes A, Marrón C, Veras M, Librizzi MS, Calatayud M.   +5 more
europepmc   +1 more source