Results 131 to 140 of about 202,243 (244)
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Neuroendocrine tumours of the pancreas
Journal of British Surgery, 2000 B, Eriksson, K, Oberg
openaire +2 more sources
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Percutaneous Laser Thermal Ablation in a Patient with 22 Liver Metastases from Pancreatic Neuroendocrine Tumours: A Case Report [PDF]
, 2018 The relatively indolent nature of well-differentiated neuroendocrine tumours (NET) and their proclivity to be hormonally active warrants aggressive multimodal treatment, even for advanced stage disease.
Paola Tombesi +3 more
core
Early Experience With Evoque Transcatheter Tricuspid Valve Replacement in Carcinoid Heart Disease
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Tricuspid regurgitation (TR) is nearly universal in carcinoid heart disease (CHD), but surgical replacement carries significant risk, and CHD was excluded from the landmark TRISCEND II trial. We present seven patients with CHD undergoing Evoque transcatheter tricuspid valve replacement (TTVR) at two tertiary centers.
Jackson S. Burton +3 more
wiley +1 more source
, 2012 BACKGROUND: Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into three classes. While class I isoforms have been well-studied in cancer, little is known about the functions of class II PI3Ks.
Guerreiro, Ana S +21 more
core
Small Intestinal, Colorectal, and Appendicular Neuroendocrine Tumors
Intestinal neuroendocrine tumors (NETs) arise from the diffuse endocrine system present throughout its submucosal lining. These tumor cells are typically well-differentiated, slow growing, store various peptides and amino acids that, when secreted, can ...
Gupta, Garima +2 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong +10 more
wiley +1 more source
[Localization diagnostics of neuroendocrine gastrointestinal tumours]
, 2010 Localization diagnostics of neuroendocrine tumours is relevant in relation to staging and planning of therapy, including surgery. Imaging modalities are also relevant in relation to biopsy guidance.
Knigge, Ulrich +4 more
core +1 more source