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Annual Review of Pathology: Mechanisms of Disease, 2007
As familial cancer syndromes, the neurofibromatoses exhibit complex phenotypes, comprising a range of tumor and nontumor manifestations. Although the three recognized forms of neurofibromatosis (NF1, NF2, and schwannomatosis) all feature the development of nervous system tumors, their underlying genetic bases are clearly distinct.
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As familial cancer syndromes, the neurofibromatoses exhibit complex phenotypes, comprising a range of tumor and nontumor manifestations. Although the three recognized forms of neurofibromatosis (NF1, NF2, and schwannomatosis) all feature the development of nervous system tumors, their underlying genetic bases are clearly distinct.
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Neurologic Clinics, 2002
Neurofibromatosis 1 is one of the most common genetic conditions affecting the nervous system. Individuals with NF1 are predisposed to the development of peripheral nerve sheath tumors (neurofibromas and MPNSTs), astrocytomas (optic pathway gliomas), learning disabilities, seizures, strokes, macrocephaly, and vascular abnormalities.
Timothy M, Lynch, David H, Gutmann
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Neurofibromatosis 1 is one of the most common genetic conditions affecting the nervous system. Individuals with NF1 are predisposed to the development of peripheral nerve sheath tumors (neurofibromas and MPNSTs), astrocytomas (optic pathway gliomas), learning disabilities, seizures, strokes, macrocephaly, and vascular abnormalities.
Timothy M, Lynch, David H, Gutmann
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There are two types of neurofibromatosis (NF): NF1 (type 1, peripheral NF, or von Recklinghausen syndrome); NF2 (type 2, central or bilateral acoustic NF). The mode if inheritance is autosomal dominant.
Jennifer, Adeghate +2 more
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Jennifer, Adeghate +2 more
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Meningiomas and neurofibromatosis
Journal of Neuro-Oncology, 2010Neurofibromatosis type 2 (NF2) is a rare genetic disorder predisposing to multiple benign tumors of the nervous system. Meningiomas occur in about half of NF2 patients, and are often multiple. Patients harboring seemingly isolated multiple meningiomas should be investigated to diagnose NF2 by careful familial history collection, detailed clinical ...
Stéphane, Goutagny, Michel, Kalamarides
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The pedicle in neurofibromatosis
American Journal of Roentgenology, 1978Three cases of von Recklinghausen's disease (neurofibromatosis) are described, one with agenesis of a pedicle, another with multiple hypoplastic pedicles, and a third with bilateral hypoplastic pedicles producing a spondylolistesis. These peidcle deficiencies are manifestations of mesodermal dysplasia.
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Macrocranium and Neurofibromatosis
Radiology, 1973Abstract Of 34 children with neurofibromatosis, 30% had macrocranium as defined by head circumference and 75% by radiographic criteria. The study suggests that macrocranium may be an expression of neurofibromatosis.
K A, Weichert +3 more
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Current Opinion in Neurology, 2003
Recent clinical and molecular research on neurofibromatosis 2 (NF2) is reviewed, and the implications for clinical practice and research are discussed.NF2 patients who are treated in specialty centers have a significantly lower risk of mortality than those who are treated in non-specialty centers. Vestibular schwannoma growth rates in NF2 are generally
Michael E, Baser +2 more
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Recent clinical and molecular research on neurofibromatosis 2 (NF2) is reviewed, and the implications for clinical practice and research are discussed.NF2 patients who are treated in specialty centers have a significantly lower risk of mortality than those who are treated in non-specialty centers. Vestibular schwannoma growth rates in NF2 are generally
Michael E, Baser +2 more
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Neurofibromatosis and Schwannomatosis
Seminars in Neurology, 2018Neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis are a group of related classically inherited but often times sporadic tumor suppressor syndromes. Neuro-oncologists should recognize these syndromes, initiate necessary tests in patients with a clinical suspicion, and support genetic counseling of patients and families.
Scott R, Plotkin, Antje, Wick
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Acta Orthopaedica Scandinavica, 1986
Neurofibromatosis occurs once in every 3,000 live births. Café au lait spots are the most common presenting lesion. Five spots with a diameter of at least 0.5 cm. should be considered diagnostic in children. Spinal deformity is the most common bony lesion. Scoliosis varies from mild nonprogressive forms to hairpin curvatures.
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Neurofibromatosis occurs once in every 3,000 live births. Café au lait spots are the most common presenting lesion. Five spots with a diameter of at least 0.5 cm. should be considered diagnostic in children. Spinal deformity is the most common bony lesion. Scoliosis varies from mild nonprogressive forms to hairpin curvatures.
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Gastrointestinal Neurofibromatosis
Journal of Clinical Gastroenterology, 1984Progressive anemia, melena, and sudden massive upper gastrointestinal bleeding in a man with cutaneous neurofibromatosis (von Recklinghausen's disease) since childhood prompted endoscopic demonstration of multiple gastric neurofibromas. One source of gastric bleeding removed by endoscopic electrosurgery proved to be a malignant schwannoma (spindle cell
J M, Petersen, D R, Ferguson
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