Results 131 to 140 of about 44,772 (247)

Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Lynch syndrome (LS), a well‐known cancer risk syndrome, is caused by deleterious germline mutations in the mismatch repair genes. LS predispose patients to various types of cancers including colon adenocarcinoma. We discuss the case of a woman with LS who also developed a non‐functioning pancreatic neuroendocrine tumor (P‐NET) following ...
Fateme Salemi, Zahra Sadin, Atefe Barzegari, Seyed Mohammad Reza Mortazavizadeh, Massih Bahar, Motahare Amiri   +5 more
wiley   +1 more source

Cutaneous Adverse Drug Reactions Associated With BRAF and MEK Inhibitors: A Real‐World Analysis of WHO Pharmacovigilance Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 274-285, July 2026.
BRAF inhibitors and MEK inhibitors (MEKi) have reshaped the treatment of BRAFV600‐mutant malignancies; however, cutaneous adverse drug reactions (ADRs) remain a frequent and clinically impactful toxicity. Although clinical trials provide insight into their safety profiles, real‐world data on dermatologic ADRs are limited.
Natalia Sauer, Piotr Giedziun, Jacek Calik, Anna Wiela‐Hojeńska   +3 more
wiley   +1 more source

Neurofibromatosis tipos 1 y 2

Revista del Hospital Italiano de Buenos Aires
La neurofibromatosis (NF) comprende un grupo de enfermedades genéticas de herencia autosómica dominante, que se clasifican de la siguiente manera: neurofibromatosis tipo 1 (NF1), neurofibromatosis tipo 2 (NF2) y schwannomatosis (también conocida como ...
María Florencia Correa, Natalia Inés Pasik   +1 more
doaj  

Neurofibromatosis: chronological history and current issues Neurofibromatose: histórico cronológico e aspectos atuais

Anais Brasileiros de Dermatologia, 2013
Neurofibromatosis, which was first described in 1882 by Von Recklinghausen, is a genetic disease characterized by a neuroectodermal abnormality and by clinical manifestations of systemic and progressive involvement which mainly affect the skin, nervous ...
João Roberto Antônio, Eny Maria Goloni-Bertollo, Lívia Arroyo Trídico   +2 more
doaj  

Attrition in Cochlear Implant Research: Sociodemographic, Audiologic, and Performance Variables

The Laryngoscope, Volume 136, Issue 7, Page 3195-3202, July 2026.
In a retrospective review of attrition patterns for participants in a clinical research study, sociodemographic variables were not significantly different between those who elected to withdraw and those who completed the study. Those in the withdrawal group had poorer low‐frequency residual hearing, were less likely to be electric‐acoustic stimulation ...
Amanda D. Sloop, Margaret E. Richter, Samantha P. Scharf, Meredith A. Rooth, Kevin D. Brown, Margaret T. Dillon   +5 more
wiley   +1 more source

Aging and Hearing with Vestibular Schwannoma Beyond Presbycusis: A Large Cross‐Sectional Audiometric and Volumetric Study

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective To identify predictors of auditory function in treatment‐naïve vestibular schwannomas (VS) while accounting for age‐related hearing loss, investigating baseline volumetrics and audiometrics in a pre‐intervention stereotactic radiosurgery (SRS) cohort. Study Design Cross‐sectional study.
Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadwe, Jérome R. Lechien, Daniele Morelli, Cécile Renier, Nicolas Massager   +6 more
wiley   +1 more source

Neurofibromatosis type 1 in a child of a parent with segmental neurofibromatosis (NF-5) [PDF]

, 1989
Neurofibromatosis type 1 (NF-1) was incidentally diagnosed in a 1-year-old girl. Her father was found to show the cutaneous signs of segmental neurofibromatosis (NF-5).
Mächler, Marco, Stocker, H, Boltshauser, Eugen; https://orcid.org/   +2 more
core  

Complete Resection of a Middle Mediastinal Malignant Peripheral Nerve Sheath Tumour via a Transmanubrial Osteomuscular Sparing Approach: A Case Report

Respirology Case Reports, Volume 14, Issue 7, July 2026.
We report a rare middle mediastinal malignant peripheral nerve sheath tumour. Preoperative imaging showed contact with vital structures, raising concern for resectability. However, complete resection was achieved using a transmanubrial osteomuscular sparing approach.
Minoru Sugihara, Shota Nakamura, Heng Huang, Taiki Ryo, Yoshito Imamura, Yasuhisa Ichikawa, Tatsuya Masuda, Hirofumi Takenaka, Hiroki Watanabe, Yuta Kawasumi, Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Tetsuya Mizuno, Toyofumi Fengshi Chen‐Yoshikawa   +15 more
wiley   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC

Cancer Science, Volume 117, Issue 7, Page 1795-1812, July 2026.
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang, Cuiwei Liu, Zihan Xia, Ting Hu, Yuting Li, Dan Han, Yunjie Song, Yuxi Ma, Yanxia Zhao   +8 more
wiley   +1 more source