Results 31 to 40 of about 1,567,257 (239)

Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors

Frontiers in Oncology, 2022
Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas which lack effective drugs. Loss of the RAS GTPase-activating protein NF1 and subsequent overactivation of mitogen-activated protein kinase kinase (MAPK) signaling exist
Yihui Gu, Chengjiang Wei, Manhon Chung, Haibo Li, Zizhen Guo, Manmei Long, Yuehua Li, W. Wang, Rehanguli Aimaier, Qingfeng Li, Zhichao Wang   +10 more
semanticscholar   +1 more source

Giant plexiform neurofibroma of lower limb: Importance of radiology in diagnosis, complications and management

Ibom Medical Journal, 2022
Plexiform neurofibromatosis is reported to occur in 26.7% of patients with type I neurofibromatosis. Plexiform neurofibromas present at, or soon after, birth as areas of hyperpigmentation, thickening of the skin and excess hair.
Udeagu GC, Njeze NR, Ukwuaku CC
doaj   +1 more source

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Orphanet Journal of Rare Diseases, 2020
Background Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity.
A. Moramarco, F. Mallone, M. Sacchetti, Luca Lucchino, E. Miraglia, V. Roberti, A. Lambiase, S. Giustini   +7 more
semanticscholar   +1 more source

Giant intrthoracic meningoceles associated with cutaneous neurofibromatosis type I: case report [PDF]

Arquivos de Neuro-Psiquiatria, 2003
BACKGROUND: Intrathoracic meningocele is a rare pathology, almost always associated with neurofibromatosis type I and with a few cases related in the literature.
Guilherme Cabral de Andrade, Otávio Piccirillo Braga, Marcelo Ken-Iti Hisatugo, Manuel Antônio de Paiva Neto, Ernesto Succi, Fernando Menezes Braga   +5 more
doaj   +1 more source

Notching in the Posterior Border of the Ramus of Mandible in a Patient with Neurofibromatosis Type I – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2013
Neurofibromatosis Type I (NFI) is a relatively common hereditary, autosomal dominant neurocutaneous condition. It is a benign peripheral nerve sheath tumour arising from Schwann cells and peripheral fibroblasts.
Bhuvana Krishnamoorthy, Parul Singh, Suma Gundareddy N, Manisha Lakhanpal Sharma, Manu Dhillon   +4 more
doaj   +1 more source

Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I related Plexiform Neurofibromas

Clinical Cancer Research, 2020
Purpose: Simultaneously targeting the tumor and tumor microenvironment may hold promise in treating children with refractory solid tumors. Pexidartinib, an oral inhibitor of tyrosine kinases including colony stimulating factor 1 receptor (CSF-1R), KIT ...
Lauren H Boal, J. Glod, Melissa Spencer, M. Kasai, J. Derdak, E. Dombi, M. Ahlman, Daniel W. Beury, M. Merchant, Christianne Persenaire, D. Liewehr, S. Steinberg, B. Widemann, R. Kaplan   +13 more
semanticscholar   +1 more source

Computed Tomography–Based Differentiation of Benign and Malignant Craniofacial Lesions in Neurofibromatosis Type I Patients: A Machine Learning Approach

Frontiers in Oncology, 2020
Background: Because neurofibromatosis type I (NF1) is a cancer predisposition disease, it is important to distinguish between benign and malignant lesions, especially in the craniofacial area.
Chengjiang Wei, Cheng Yan, Yan Tang, Wei Wang, Yihui Gu, Jieyi Ren, Xi-Wei Cui, Xiang Lian, Jin Liu, Huijing Wang, B. Gu, T. Zan, Qing-Feng Li, Zhichao Wang   +13 more
semanticscholar   +1 more source

Neurofibroma of the Palate

Case Reports in Dentistry, 2014
Neurofibroma is a benign peripheral nerve sheath tumor comprising variable mixture of Schwann cells, perineurial-like cells, and fibroblasts. Neurofibroma may occur as solitary lesion or as part of a generalised syndrome of neurofibromatosis or very ...
Tirumalasetty Sreenivasa Bharath, Yelamolu Rama Krishna, Govind Rajkumar Nalabolu, Swetha Pasupuleti, Suneela Surapaneni, Suresh Babu Ganta   +5 more
doaj   +1 more source

Risk factors for intraoperative hemorrhage of Type I neurofibromatosis

BMC Surgery, 2023
Introduction Neurofibromatosis (NF) is an inherited disease and a benign tumor originating from nerve sheath cells. Neurofibromatosis type I (NF1) is the most common type, and most cases are characterized by neurofibromas. Neurofibromas in NF1 are mainly
Qianqian Gao, Siwei Qu, Ning Ma, Weixin Wang, Sen Chen, Zhe Yang, Yangqun Li   +6 more
doaj   +1 more source

The neurofibromatosis type I gene promotes autophagy via mTORC1 signalling pathway to enhance new bone formation after fracture

Journal of Cellular and Molecular Medicine, 2020
Bone fracture is one of the most common injuries. Despite the high regenerative capacity of bones, failure of healing still occurs to near 10% of the patients.
Q. Tan, Jiang-yan Wu, Yao-xi Liu, Kun Liu, Jin Tang, W. Ye, G. Zhu, H. Mei, Ge Yang   +8 more
semanticscholar   +1 more source