Results 61 to 70 of about 1,567,257 (239)
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Type 1 neurofibromatosis complicated by pulmonary arterial hypertension: a case report
Türk Kardiyoloji Derneği Arşivi, 2017 Neurofibromatosis type I (NF1) is a rare genetic disease caused by mutations in the NF1 gene, which encodes the tumor suppressor neurofibromin. Precapillary pulmonary hypertension is a severe complication of NF1, initially described in patients with ...
Murathan Küçük +3 more
doaj +1 more source
Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review
Clinical Anatomy, EarlyView.ABSTRACT Facial transplantation is a division of reconstructive surgery which aims to improve the function and appearance of a face that has endured severe disfigurement. Currently, the face transplant procedure uses allogenic tissue, harvested from a brain‐dead donor, to replace damaged facial components.
Olivia A. James, Faye Bennett
wiley +1 more source
Facial Plexiform Neurofibromatosis Type I
Bengal Journal of Otolaryngology and Head Neck Surgery, 2018 Introduction Plexiform neurofibroma is a benign tumor of peripheral nerves arising from a proliferation of all neural elements. Clinically, it presents as a subcutaneous mass which feels like a "bag of worms".
Bapan Devnath, Debraj Dey, Avinava Ghosh
doaj
Revista Brasileira de Cancerologia, 2023 Introduction: Gastrointestinal stromal tumors (GIST), although relatively rare, account for 80% of mesenchymal tumors of the digestive tract. They manifest in any part of the alimentary tract and are derived from Cajal cells. They may occur sporadically
Pamela Viana e Silva +3 more
doaj +1 more source
Neurosurgical implications of neurofibromatosis Type I in children
Neurosurgical Focus, 2006 Neurofibromatosis Type 1 (NF1) is one of the most common inherited diseases in humans. It is caused by a mutation in the NF1 gene on chromosome 17, and is associated with numerous central and peripheral nervous system manifestations.
Merdas, Al-Otibi, James T, Rutka
openaire +2 more sources
A rare case of neurofibromatosis type I with unilateral congenital ectropion uveae and glaucoma
American Journal of Ophthalmology Case Reports, 2020 Purpose Neurofibromatosis Type I (NF-1) is a neurocutaneous disease affecting the skin, eye and peripheral nervous system. Congenital glaucoma is a rare association, but can be a prelude to the diagnosis of NF-1 later in life.
P. Venkataraman +2 more
semanticscholar +1 more source
Retrospective Analysis of T2‐Hyperintense Lesions in Children With Neurofibromatosis Type 1
Annals of the Child Neurology Society, EarlyView.ABSTRACT Objective The aim of this study is to determine whether a previously reported three‐tiered classification scheme for T2‐hyperintense brain lesions in children with neurofibromatosis type 1 (NF1) was associated with distinct radiographic or clinical characteristics after 10 years of real‐world follow‐up data were obtained.
Ariel B. Brickler +4 more
wiley +1 more source
Motor Learning in Children with Neurofibromatosis Type I [PDF]
The Cerebellum, 2010 The aim of this study was to quantify the frequently observed problems in motor control in Neurofibromatosis type 1 (NF1) using three tasks on motor performance and motor learning. A group of 70 children with NF1 was compared to age-matched controls. As expected, NF1 children showed substantial problems in visuo-motor integration (Beery VMI).
Krab, L.C. +6 more
openaire +3 more sources
Gene diagnosis of infantile neurofibromatosis type I: A case report
World Journal of Clinical Cases, 2020 BACKGROUND Neurofibromatosis is an autosomal dominant genetic disorder with various manifestations. Systemic multiple neurofibromatosis is rare in infancy.
Mengzhu Li, Lin Yuan, Z. Zhuo
semanticscholar +1 more source