Results 141 to 150 of about 21,804 (172)
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Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning
Bone, 2005Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associated with altered bone homeostasis and
X, Yu +11 more
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Loss of Neurofibromin in the Leptomeningeal Astroglial Heterotopia of NF-1
Pediatric Neurology, 1998Neurofibromin, the protein product of the neurofibromatosis type 1 (NF-1) gene, has important roles in tumor suppression or normal embryogenesis. Cerebellar leptomeningeal astroglial heterotopia (LAH) is a proliferation of heterotopic astroglial cells and fibers in the cerebellar leptomeninges, which is characteristically demonstrated in the NF-1 ...
M, Kato +4 more
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Neurofibromin-deficient fibroblasts fail to form perineurium in vitro
Development, 1995ABSTRACT To identify cell type(s) that might contribute to nerve sheath tumors (neurofibromas) in patients with neurofibromatosis type 1, we generated cell cultures containing neurons, Schwann cells and fibroblasts from transgenic mouse embryos in which the type 1 neurofibromatosis gene was disrupted by homologous recombination (Brannan ...
T, Rosenbaum +6 more
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Journal of child neurology, 2003
Neurofibromatosis 1 is one of the most common autosomal dominant disorders affecting the nervous system. Individuals with neurofibromatosis 1 present with abnormalities of both astrocytes and neurons that result from reduced or absent expression of the NF1 gene product neurofibromin.
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Neurofibromatosis 1 is one of the most common autosomal dominant disorders affecting the nervous system. Individuals with neurofibromatosis 1 present with abnormalities of both astrocytes and neurons that result from reduced or absent expression of the NF1 gene product neurofibromin.
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Neurofibromin and Neuronal Apoptosis
2003Abstract : Our purpose is to examine the role of neurofibromin in modulating the survival of embryonic sensory and sympathetic neurons. To understand how reduced neurofibromin levels might impact the survival responses to activity-mediated signaling (mimicked with KCl) and to neurotrophins, we used dissociated cultures of Nf1+/- and exon23a-/- sensory ...
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Review Article : Neurofibromin in the Brain
Journal of Child Neurology, 2002Neurofibromatosis 1 is one of the most common autosomal dominant disorders affecting the nervous system. Individuals with neurofibromatosis 1 present with abnormalities of both astrocytes and neurons that result from reduced or absent expression of the NF1 gene product neurofibromin.
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Structural basis of activation of the tumor suppressor protein neurofibromin
Molecular Cell, 2022Sebastiaan Werten +2 more
exaly
Neurofibromin, a Tumor Suppressor in the Nervous System
Experimental Cell Research, 2001Y, Zhu, L F, Parada
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