Results 101 to 110 of about 22,402 (163)

Supplementary Methods, Figure Legends 1-4 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling

, 2011
Supplementary Methods, Figure Legends 1-4 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad ...
Yoel Kloog (196187), Marcelo Ehrlich (108109), Batya Barkan (14898749)   +2 more
core   +1 more source

From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation

, 2012
Both Neurofibromatosis type I (NF1) and inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) are autosomal dominant genetic disorders.
Yi-Ping Hsueh, Hsueh Yi-Ping
core   +1 more source

The interaction of p21Ras with neurofibromin [PDF]

, 1997
rasgenes encode guanine nucleotide binding proteins that act as molecular switches for signal transduction pathways controlling cell growth and differentiation.
Sermon, Beth A.
core  

Structural analysis of the GAP-related domain from neurofibromin and its implications

, 1998
Neurofibromin is the product of the NF1 gene, whose alteration is responsible for the pathogenesis of neurofibromatosis type 1 (NF1), one of the most frequent genetic disorders in man.
Stege, P., Wittinghofer, A., Ahmadian, M., Scheffzek, Klaus, Schmitz, Frank, Ahmadian, Mohammad Reza, Stege, Patricia, Wittinghofer, Alfred, Schmitz, F., Wiesmüller, L., Kabsch, W., Kabsch, Wolfgang, Scheffzek, K., Wiesmüller, Lisa   +13 more
core   +1 more source

The Roles of Ras and Neurofibromin 1 in Human Neuroblastoma Stem Cell Malignancy

, 2011
Cancer stem or tumor-initiating cells are present in many human cancers. However, the molecular mechanisms responsible for the clinical aggressiveness of these cells are still unclear.
Han, Dan
core  

Novel insights into neurofibromin function and human neurofibromatosis type 1 mutations using genetically engineered mouse models

, 2018
Loss of NF1 in different developmental and cellular contexts leads to unique physiological outcomes due to loss of neurofibromin function, including embryonic lethality, sporadic cancers, and the genetic disorder NF1.
Turner, Ashley Nicole
core  

Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP

, 1994
The activation of Ras proteins is a key step in the signal transduction pathways triggered by ligand-bound cell surface receptors. The GTPase activating proteins (GAPs) p120-GAP and neurofibromin, the neurofibromatosis-type 1 (NF1) gene product, are ...
Boyer, M. J., Collins, F. S., Gutmann, D. H., Bar-Sagi, D.   +3 more
core  

Neurofibromatosis Type 1 Tumor Suppressor, Neurofibromin, Regulates the Neuronal Differentiation of PC12 cells via its Associating Protein, CRMP-2

, 2008
application/pdf学位論文(Thesis)To understand the role of neurofibromin in neuronal cells, we identified a set of cellular proteins associating to neurofibromin with a newly developed proteomic strategy, and found that a group of neuronal proteins such as an ...
105702, Patrakitkomjorn, Siriporn
core  

Neurofibromin 1 (<i>NF1</i>) Splicing Mutation c.61-2A>G: From Aberrant mRNA Processing to Therapeutic Implications In Silico. [PDF]

Int J Mol Sci
Blazyte A, Lee H, Yoon C, Jeon S, Lee J, Bayarsaikhan D, Kim J, Park S, Cho J, Baek SA, Byun G, Lee B, Bhak J.   +12 more
europepmc   +1 more source