Results 101 to 110 of about 25,840 (207)
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim +6 more
wiley +1 more source
Unraveling neuronal and metabolic alterations in neurofibromatosis type 1
Journal of Neurodevelopmental DisordersNeurofibromatosis type 1 (OMIM 162200) affects ~ 1 in 3,000 individuals worldwide and is one of the most common monogenetic neurogenetic disorders that impacts brain function.
Valentina Botero, Seth M. Tomchik
doaj +1 more source
The chaperone TRAP1 as a modulator of the mitochondrial adaptations in cancer cells [PDF]
, 2017 Mitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling ...
Colombo, Giorgio +3 more
core +2 more sources
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source
Cell Reports, 2014 Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder associated with attention deficits and learning disabilities. The primary known function of neurofibromin, encoded by the NF1 gene, is to downregulate Ras activity.
Marc A. Wolman +5 more
doaj +1 more source
Homozygosity at variant MLH1 can lead to secondary mutation in NF1, neurofibromatosis type I and early onset leukemia [PDF]
, 2008 Cataloged from PDF version of article.Heterozygous germ-line variants of DNA mismatch repair (MMR) genes predispose individuals to hereditary non-polyposis colorectal cancer.
Alotaibi, H. +2 more
core +2 more sources
FEBS Open Bio, Volume 16, Issue 2, Page 268-278, February 2026.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
The Molecular Mechanism and Therapeutic Progress in Glomus Tumor
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Background Glomus tumor (GT) is a rare mesenchymal neoplasm presumed to originate from the neuromyoarterial glomus body. Its pathogenesis is complex and involves alterations in multiple genes and signaling pathways. In the era of precision medicine, increased molecular research has begun to elucidate the oncogenic drivers of GT, offering novel
Zhi Cheng Jiang +7 more
wiley +1 more source
Enriched expression of NF1 in inhibitory neurons in both mouse and human brain
Molecular Brain, 2019 Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by loss-of-function mutations in NF1 gene, which encodes a GTPase activating protein for RAS.
Hyun-Hee Ryu +4 more
doaj +1 more source
Gene expression analysis of aberrant signaling pathways in meningiomas [PDF]
, 2013 Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor-related genes in meningiomas.
Burbano, Rommel Rodríguez Rodríguez +10 more
core +2 more sources