Results 101 to 110 of about 22,652 (194)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Recent Advancement of Neurofibromatosis Type 1: A Narrative Review
Acta Neurologica TaiwanicaNeurofibromatosis type 1 (NF1) is a complex autosomal dominant genetic disorder caused by mutations in the NF1 gene on chromosome 17, which encodes the tumor-suppressor protein, neurofibromin.
Po-Yuan Huang +2 more
doaj +1 more source
Scientific Reports, 2018 Neurofibromatosis type 1 (NF1) is caused by germline mutations in the NF1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas.
Ritsuko Harigai +13 more
doaj +1 more source
Neurofibromin (Nf1) is required for skeletal muscle development [PDF]
, 2011 Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signaling.
Robinson, P. +11 more
core
Neurofibromin is the major ras inactivator in dendritic spines [PDF]
, 2014 In dendritic spines, Ras plays a critical role in synaptic plasticity but its regulation mechanism is not fully understood. Here, using a fluorescence resonance energy transfer/fluorescence lifetime imaging microscopy-based Ras imaging technique in ...
Yasuda, R., Oliveira, A.
core +1 more source
Virology, 2008 Virus-host interactions essential for alphavirus pathogenesis are poorly understood. To address this shortcoming, we coupled retrovirus insertional mutagenesis and a cell survival selection strategy to generate clonal cell lines broadly resistant to Sindbis virus (SINV) and other alphaviruses.
Kolokoltsova, Olga A. +5 more
openaire +2 more sources
A neurofibromatosis type 1 family report with multiple cases in 3 consecutive Generations
مجله دانشگاه علوم پزشکی گرگان, 2017 Neurofibromatosis type1 (NF1) with the incidence of 1 in 3500 births, is the most common disorder which affects skin and peripheral nervous system. NF1 results from mutations in NF1 gene. The NF1 gene spans 350kbp and to date, nearly 2434 mutations in it
M Oladnabi +4 more
doaj
Supplementary Methods, Figure Legends 1-4 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling [PDF]
, 2011 Supplementary Methods, Figure Legends 1-4 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad ...
Yoel Kloog (196187) +2 more
core +1 more source
Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene
Case Reports in Oncological Medicine, 2014 Background. Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1) which codifies the protein neurofibromin.
Gustavo Fernandes +4 more
doaj +1 more source
The NF1 somatic mutational landscape in sporadic human cancers
Human Genomics, 2017 Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome.
Charlotte Philpott +4 more
doaj +1 more source