Results 31 to 40 of about 30,010,976 (156)
Cell Reports, 2020 Summary: Neurofibromatosis type 1 (NF1) is a dominant genetic disorder manifesting, in part, as cognitive defects. Previous study indicated that neurofibromin (NF1 protein) interacts with valosin-containing protein (VCP)/P97 to control dendritic spine ...
Yu-Tzu Shih +4 more
doaj +1 more source
Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation [PDF]
, 1993 Neurofibromin, the product of the neurofibromatosis type 1 (NF1) gene, is a ∼250 kDa protein expressed predominantly in cortical neurons and oligodendrocytes in the central nervous system (CNS) and sensory neurons and Schwann cells in the peripheral ...
J. L. Cole +9 more
core +1 more source
, 1997 Review on NF1 (neurofibromin 1), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core +1 more source
Cells, 2020 Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis ...
Charoula Peta +4 more
doaj +1 more source
The kinetic mechanism of the interaction of p21ras with neurofibromin [PDF]
, 1997 This project involved examining the mechanism of interaction of the 21kDa guanine nucleotide binding protein, N-ras, with the catalytic domain of the GTPase-activating protein, neurofibromin.
Jenkins, Tracy
core +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Neurofibromatosis in Children: Actually and Perspectives
Children, 2022 The three types of neurofibromatosis, namely type 1, type 2, and schwannomatosis, are generally associated with various benign tumors affecting the skin and the nervous system. On rare occasions, especially in patients with neurofibromatosis type 1 (NF1),
Maria Lucia Sur +8 more
doaj +1 more source
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Localization of Neurofibromin to Keratinocytes and Melanocytes in Developing Rat and Human Skin [PDF]
, 1994 Pigmentation defects are common in the inherited disease type 1 neurofibromatosis (NF1), predicting a role for the NF1 gene product, neurofibromin, in the skin.
Malhotra, Ritu, Ratner, Nancy
core +1 more source
Cell ReportsSummary: Persons with neurofibromatosis type 1 (NF1) exhibit enhanced glucose metabolism, which is replicated in Nf1-mutant mice. Inflammatory macrophages invest NF1-associated tumors, and targeting macrophages appears efficacious in NF1 models ...
Yusra Zaidi +20 more
doaj +1 more source