Results 1 to 10 of about 25,034,870 (238)

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2 [PDF]

Nature Communications, 2018
Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for ...
Krishna Chinthalapudi, Jie Zheng, Patrick R Griffin   +2 more
exaly   +8 more sources

Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway [PDF]

European Journal of Medical Research
Thromboangiitis obliterans (TAO) is characterized by progressive inflammatory vasculopathy featuring thrombotic occlusion. Aberrant thrombosis induces endothelial damage through pathological clotting, while iron may act as a pro-oxidant cofactor. However,
Ying Deng, Xueguang Lin, Jun Wei, Bo Chen, Huafang Yan, Bo Wang, Jialong Li, Yuqun Zhao, Bo Yu, Jingdong Tang, Shuai Jiang   +10 more
doaj   +4 more sources

Neurofibromin 2 modulates Mammalian Ste2-like kinases1/2 and large tumor suppressor gene1 expression in A549 lung cancer cell line. [PDF]

Am J Transl Res
AIM To explore the impact of up- or down-regulation of Neurofibromin 2 (NF2) on the expression of downstream Hippo pathway genes, large tumor suppressor gene1 (LATS1), and phosphorylation of Mammalian Ste2-like kinases1/2 (MST1/2), in lung cancer cells.
Li X, Guo Z, Yang Y, Xiong Y, Zhang X, Qiao S, Wei K, Fang J, Ma Y.   +8 more
europepmc   +4 more sources

Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies [PDF]

Scientific Reports
Germline mutations in the NF1 gene disrupt neurofibromin function, leading to autosomal-dominant neurofibromatosis type I (NF1). As a tumor suppressor, neurofibromin negatively regulates the RAS signaling.
Jianmei Huang, Ke Yang, Yaoping Wang, Xinrui Ma, Wenke Yang, Xiaodong Huo, Jie Bai, Hongjie Zhu, Jinming Wang, Yibing Lv, Shixiu Liao   +10 more
doaj   +2 more sources

Genomic profile of human meningioma cell lines. [PDF]

PLoS ONE, 2017
Meningiomas, derived from arachnoid cap cells, are the most common intracranial tumor. High-grade meningiomas, as well as those located at the skull base or near venous sinuses, frequently recur and are challenging to manage.
Yu Mei, Wenya Linda Bi, Noah F Greenwald, Nathalie Y Agar, Rameen Beroukhim, Gavin P Dunn, Ian F Dunn   +6 more
doaj   +2 more sources

PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway

Journal of Neuroinflammation, 2023
Background Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin).
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang   +5 more
doaj   +2 more sources

Diagnostic and therapeutic process of neurofibromatosis type 1 and type 2

Journal of Education, Health and Sport
Neurofibromatosis is one of the most common genetic diseases. It is inherited in an autosomal dominant manner. It is divided into two genetically distinct subtypes, characterised by multiple skin lesions and tumours of the peripheral and central nervous 
Michał Leśniewski, Iwona Welian-Polus, Izabela Oleksak, Karolina Maliszewska   +3 more
doaj   +2 more sources

Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration

Nature Communications
Skeletal mesenchymal stem cells (MSCs) possess self-renewal capacities and play a leading role in the craniofacial system. However, their engagement in controlling cranial bone development and regeneration remains largely unidentified.
Junguang Liao, Yuping Huang, Fuju Sun, Chenggong Zheng, Yifeng Yao, Cui Zhang, Chenhe Zhou, Xingen Zhang, Mengrui Wu, Guiqian Chen   +9 more
doaj   +2 more sources

LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway

Communications Biology
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis.
Rongrong Zhang, Yating Zhan, Zhichao Lang, Yifei Li, Weizhi Zhang, Jianjian Zheng   +5 more
doaj   +2 more sources

Merlin regulates signaling events at the nexus of development and cancer

Cell Communication and Signaling, 2020
Background In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure normal ontogeny, and we discuss how Merlin deficiency leads to aberrant activation of ...
Mateus Mota, Lalita A. Shevde
doaj   +2 more sources