Results 111 to 120 of about 25,034,870 (238)

The Role of Merlin/NF2 Loss in Meningioma Biology

Cancers, 2019
Mutations in the neurofibromin 2 (NF2) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on analysis of neurofibromatosis type 2 (NF2) patients who not only develop vestibular schwannomas but later have a high ...
Sungho Lee, Patrick J. Karas, C. Hadley, J. Bayley V, A. B. Khan, Ali Jalali, A. Sweeney, Tiemo J. Klisch, Akash J. Patel   +8 more
semanticscholar   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, Volume 99, Issue 1, Page 73-83, January 2026.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

K-Ras protein as a drug target [PDF]

, 2016
K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one million cancer cases/year. In cancers driven by mutant K-Ras, the protein is locked in the active, GTP-bound state constitutively, through a defect in the off ...
Frank McCormick
core   +2 more sources

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma [PDF]

, 2018
Conventional differential expression analyses have been successfully employed to identify genes whose levels change across experimental conditions.
Bush, Erin C, Duron, Christina, Gutmann, David H, Hardin, Johanna, Ma, Yu, Pan, Yuan, Radunskaya, Ami, Sims, Peter A   +7 more
core   +5 more sources

Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth

Journal of Experimental & Clinical Cancer Research, 2019
Background Malignant peripheral nerve sheath tumours (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome, neurofibromatosis type 1 (NF1).
Kang Yang, Wei Guo, Tingting Ren, Yi Huang, Yu Han, Hongliang Zhang, Jie Zhang   +6 more
doaj   +1 more source

MicroRNA-195-5p targets neurofibromin 2 to mediate hyperoxia-induced alveolar dysplasia

Abstract MicroRNAs (miRs) have been shown to disrupt normal lung development and function by blocking alveolation and vascularization, leading to the development of bronchopulmonary dysplasia (BPD). However, the role of miR-195-5p in BPD has not been reported.
Dongqin Bai, Di Wu, Miao Yang, Bo Wu, Wei Xu   +4 more
openaire   +1 more source

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. [PDF]

, 2014
In Noonan syndrome (NS) 30-50% of subjects show cognitive deficits of unknown etiology and with no known treatment. Here, we report that knock-in mice expressing either of two NS-associated mutations in Ptpn11, which encodes the nonreceptor protein ...
Araki, Toshiyuki, Balaji, J, Burger, Corinna, Butz, Delana, Cai, Ying, Ehninger, Dan, Kaang, Bong-Kiun, Kang, Minkyung, Kim, Hyong Kyu, Kwak, Chuljung, Lee, Yong-Seok, Nam, Christine I, Neel, Benjamin G, Oh, Jun-Young, Ryu, Hyun-Hee, Sano, Yoshitake, Silva, Alcino J, Zhou, Miou   +17 more
core   +2 more sources

Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)

BMC Pharmacology and Toxicology, 2019
Background Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic
Yu-chi Shen, Caroline Arellano-Garcia, Rosa E. Menjivar, Ethan M. Jewett, Wolfgang Dohle, Sofiia Karchugina, Jonathan Chernoff, Barry V. L. Potter, Kate F. Barald   +8 more
doaj   +1 more source

Genomic characterization and detection of potential therapeutic targets for peritoneal mesothelioma in current practice

Clinical and Experimental Medicine (Testo stampato)
Peritoneal mesothelioma (PeM) is an aggressive tumor with limited treatment options. The current study aimed to evaluate the value of next generation sequencing (NGS) of PeM samples in current practice.
J. V. van Kooten, M. Dietz, H. Dubbink, C. Verhoef, Joachim G J V Aerts, E. Madsen, J. H. von der Thüsen   +6 more
semanticscholar   +1 more source