Results 211 to 220 of about 25,034,870 (238)

Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage

Circulation
BACKGROUND: Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways.
Chang Jie Mick Lee, Matias I. Autio, Wenhao Zheng, Yoohyun Song, Shyi-Chyi Wang, D. Wong, Jingwei Xiao, Yike Zhu, Permeen Yusoff, Xi Yei, Wan Kee Chock, B. C. Low, Marius Sudol, R. S. Foo   +13 more
semanticscholar   +1 more source

Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2a/b

Disease Models & Mechanisms
Neurofibromatosis type 2 (NF-2) is a dominantly inherited genetic disorder that results from variants in the tumor suppressor gene, neurofibromin 2 (NF2). Here, we report the generation of a conditional zebrafish model of neurofibromatosis established by
Ayyappa Raja Desingu Rajan, Yuanyun Huang, J. Stundl, Katelyn Chu, Anushka Irodi, Zihan Yang, Brian E. Applegate, Marianne E. Bronner   +7 more
semanticscholar   +1 more source

The actin-binding protein drebrin disrupts NF2-LATS kinases complex assembly to facilitate liver tumorigenesis

Hepatology
Background and Aims: The Hippo signaling has emerged as a crucial regulator of tissue homeostasis, regeneration, and tumorigenesis, representing a promising therapeutic target.
Yang Sun, Henan Wei, Wentao Yu, Haoran Gao, Jinhui Li, Xiaoyu Li, Haijiao Zhang, Haotong Zhang, S. Miao, Lihua Zhao, Ruizeng Yang, Jinjin Xu, Yi Lu, Fang Wei, Huancheng Zhou, Daming Gao, Yunyun Jin, Lei Zhang   +17 more
semanticscholar   +1 more source

Human neurofibromin 2/merlin residues 1-339 in complex with LATS1

, 2021
M. C. Primi, E. Rangarajan, T. Izard
semanticscholar   +1 more source

Novel Gbeta Mimic Kelch Proteins (Gpb1 and Gpb2 Connect G-Protein Signaling to Ras via Yeast Neurofibromin Homologs Ira1 and Ira2. A Model for Human NF1

2005
Abstract : The Neurofibromatosis type 1 (NF1) gene encodes a large tumor suppressor protein, neurofibromin, which is a Ras GTPase-activating protein (RasGAP) activity. Although the NF1 gene was identified over a decade ago, the biological roles of neurofibromin in cellular processes remain unclear. Therefore it is crucial for therapy and developing new
Toshiaki Harashima, Joseph Heitman
openaire   +2 more sources

Hippo pathway inactivation through subcellular localization of NF2/merlin in outer cells of mouse embryos.

Development
The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis and early embryogenesis. Scaffold proteins from the ezrin-radixin-moesin (ERM) family, including neurofibromin 2 (NF2; Merlin ...
Nanami Goda, Yui Ito, Shun Saito, Miyabi Suzuki, H. Bai, Masashi Takahashi, Takuya Wakai, Manabu Kawahara   +7 more
semanticscholar   +1 more source

Neurofibromin and suppression of tumorigenesis: beyond the GAP

Oncogene, 2022
Juan Mo, Renee M Mckay, Lu Q Le
exaly  

Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2

, 2018
K. Chinthalapudi, A. Sharff, G. Bricogne, T. Izard   +3 more
semanticscholar   +1 more source

Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling

Nature Communications, 2021
Pedro Machado Almeida, Luca Stickley, Alexis Feidler   +2 more
exaly  

Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

Nature Communications, 2021
Valentina Botero, Elizabeth B Brown, Tamara Boto   +2 more
exaly