Results 51 to 60 of about 25,034,870 (238)

Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways [PDF]

, 2015
Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder caused by impaired function of the neurofibromin RAS regulator. Using a combination of Nf1 genetically engineered mice and pharmacological/genetic inhibition approaches, we report ...
Chen, Yi-Hsien, Gianino, Scott M, Gutmann, David H   +2 more
core   +2 more sources

Challenges in drug discovery for neurofibromatosis type 1-associated low-grade glioma [PDF]

, 2016
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that results from germline mutations of the NF1 gene, creating a predisposition to low-grade gliomas (pilocytic astrocytoma; PA) in young children. Insufficient data and resources represent
Gutmann, David H, Keller, Charles, Pan, Yuan, Ricker, Cora A   +3 more
core   +3 more sources

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis [PDF]

, 2012
Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood.
Alessi, Bollag, Chengkai Dai, Diaz, Gitler, Gutmann, Hyoungtae Kwon, Jiayuan Shi, Junxia Cao, Khaleque, Largaespada, Luke Whitesell, Roderick T. Bronson, Sandro Santagata, Stewart, Susan Lindquist, Voellmy, Whitesell, Zheng, Zijian Tang   +19 more
core   +1 more source

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Genes & Development, 2012
The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely dispensable for normal tissue growth, suggesting that its mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP ...
Y. Liu-Chittenden, Bo Huang, J. Shim, Qian Chen, Se-Jin Lee, R. Anders, Jun O. Liu, D. Pan   +7 more
semanticscholar   +1 more source

Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology [PDF]

, 2016
Children with neurofibromatosis type 1 (NF1) develop low-grade brain tumors throughout the optic pathway. Nearly 50% of children with optic pathway gliomas (OPGs) experience visual impairment, and few regain their vision after chemotherapy.
Anne C. Solga, Arnold, Avery, Azevedo, Bajenaru, Bondesson, Compton, Daginakatte, Daginakatte, David H. Gutmann, Dennis, Diggs-Andrews, Diggs-Andrews, Fisher, Fisher, Green, Gu, Guadagno, Hegedus, Hyman, Joseph A. Toonen, Kalin-Hajdu, Kappeler, Kuiper, Listernick, Listernick, Neher, Parrilla-Reverter, Revankar, Saijo, Schneider, Simmons, Solga, Tapia-Gonzalez, Tikka, Wu, Yu Ma, Zhao   +37 more
core   +2 more sources

Supplementary Figure 2 from Sensitivity of Glioblastomas to Clinically Available MEK Inhibitors Is Defined by Neurofibromin 1 Deficiency

, 2023
<p>PDF file - 738K, Immunoblot and sub-G1 FACs analysis of NF1-deficient GBM cells treated with PD0325901 and/or PI-103</p>
Russell O. Pieper, Theodore Nicolaides, Joydeep Mukherjee, I-Li Tan, Wendy L. See   +4 more
openaire   +1 more source

2 Neurofibromin-Deficient Schwann Cells Have Increased Lysophosphatidic Acid Dependent Survival and Migration – Implications for Increased Neurofibroma Formation and Growth During Pregnancy. [PDF]

Pediatric Research, 2006
Background: During pregnancy, neurofibromas often enlarge or develop for the first time in females with neurofibromatosis type 1 (NF1). Lysophosphatidic acid (LPA) is a prototypic lysophospholipid that has been implicated in tumor progression. LPA modulates cell migration and survival of Schwann cells (SCs), and interestingly, LPA is made in increasing
T D Nebesio, X Li, S Chen, J Yuan, S A Estwick, W Ming, T L Morgan, D W Clapp, F-C Yang, Herman B Wells   +9 more
openaire   +1 more source

A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity [PDF]

, 1993
Sequence analysis has shown significant homology between the catalytic regions of the mammalian ras GTPase-activating protein (GAP), yeast Ira1p and Ira2p (inhibitory regulators of the RAS-cyclic AMP pathway), and neurofibromin, the protein encoded by ...
Andersen, L. B., Ballester, R., Marchuk, D. A., Chang, E., Gutmann, D. H., Saulino, A. M., Camonis, J., Wigler, M. H., Collins, F. S.   +8 more
core   +1 more source

Proteolytic activation of angiomotin by DDI2 promotes angiogenesis

EMBO Journal, 2023
The scaffolding protein angiomotin (AMOT) is indispensable for vertebrate embryonic angiogenesis. Here, we report that AMOT undergoes cleavage in the presence of lysophosphatidic acid (LPA), a lipid growth factor also involved in angiogenesis.
Yu Wang, Yuwen Zhu, Yebin Wang, Yue Chang, Fang Geng, Mingyue Ma, Yuan Gu, Aijuan Yu, Rui Zhu, Pengcheng Yu, Zhao Sha, Sixian Qi, Jian Li, Wencao Zhao, Weijun Pan, Ruilin Zhang, Fa-Xing Yu   +16 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source