Results 81 to 90 of about 25,034,870 (238)

Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner [PDF]

, 2012
Tandem duplications involving the BRAF kinase gene have recently been identified as the most frequent genetic alteration in sporadic pediatric glioma, creating a novel fusion protein (f-BRAF) with increased BRAF activity.
Chen, Yi-Hsien, Dahiya, Sonika, Emnett, Ryan J, Gutmann, David H, Kaul, Aparna   +4 more
core   +2 more sources

NF2 is a candidate diagnosis, prognostic, and immunotherapeutic biomarker: a systematic pan-cancer analysis

Translational Cancer Research, 2023
Background Neurofibromin 2 (NF2) regulates diverse cellular events such as transcription, translation, ubiquitination, and micro-RNA biosynthesis. Previous evidence revealed that aberrant expression of NF2 contributes to tumorigenesis in mesothelioma ...
Honglu Zhang, Jiyong Liu
semanticscholar   +1 more source

Pheochromocytoma With Langerhans Cell Histiocytosis: A Rare Tumor‐in‐Tumor Case

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Langerhans cell histiocytosis (LCH) occurring in a Pheochromocytoma in the adrenal gland is exceptionally rare and prone to misdiagnosis. The special coexistent tumors harbor distinct genetic mutations. This uncommon case could introduce novel considerations and a strong teaching message to all the clinicians and pathologists.
Cheng Lei, Yulong Guo, Yixin Luo, Qingchun Liang, Jiadi Luo   +4 more
wiley   +1 more source

Is DNA Methylation a Ray of Sunshine in Predicting Meningioma Prognosis?

Frontiers in Oncology, 2020
Meningioma is the most common intracranial tumor, and recent studies have drawn attention to the importance of further research on malignant meningioma.
Lu Shen, Danfeng Lin, Lu Cheng, Sheng Tu, Haijian Wu, Weilin Xu, Yuanbo Pan, Xiaochen Wang, Xiaochen Wang, Jianmin Zhang, Jianmin Zhang, Jianmin Zhang, Anwen Shao   +12 more
doaj   +1 more source

Merlin immunohistochemistry is useful in diagnosis of tumours within the spectrum of biphasic hyalinizing psammomatous renal cell carcinoma

Histopathology, 2022
Biphasic hyalinizing psammomatous (BHP) renal cell carcinoma (RCC) is a newly described emerging entity within the spectrum of papillary RCC in the WHO 2022 classification.
K. Collins, Michael Hwang, T. Antic, A. Paintal, P. Argani, A. Matoso, A. Gopinath, Brett Baskovich, R. Mehra, S. Williamson, Muhammad T. Idrees, J. Barletta, W. J. Anderson, M. Hirsch, J. Hornick, A. Acosta   +15 more
semanticscholar   +1 more source

Emerging genotype-phenotype relationships in patients with large NF1 deletions. [PDF]

, 2017
The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions encompassing the NF1 gene and its flanking regions (NF1 microdeletions).
Cooper, David N, Kehrer‑Sawatzki, Hildegard, Mautner, Victor‑Felix   +2 more
core   +2 more sources

Figure S2 from Proteogenomic approaches for the identification of NF1/neurofibromin-depleted estrogen receptor positive breast cancers for targeted treatment

, 2023
<p>Figure S2. Binimetinib and fulvestrant inhibited the intended targets in the two PDXs that did not regress after treatment.</p>
Eric C Chang, Matthew J. Ellis, Meenakshi Anurag, George Miles, Bing Zhang, Arun Sreekumar, Jaya Ruth Asirvatham, Bora Lim, Susan G. Hilsenbeck, Nada Mohamed, Ariella B. Hanker, Yunguan Wang, Dan Ye, Emmanuel Bikorimana, María del Rosario Chica-Parrado, Yongchao Dou, Hilda Kennedy, Purba Singh, Diana Fandino, Jianheng Peng, Anran Chen, Matthew V. Holt, Jonathan T. Lei, Ze-Yi Zheng, Beom-Jun Kim   +24 more
openaire   +1 more source

Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim, Takayuki Kondo, Keiko Imamura, Kayoko Tsukita, Ayako Nagahashi, Tomoki Sakasai, Haruhisa Inoue   +6 more
wiley   +1 more source

The NF1 somatic mutational landscape in sporadic human cancers [PDF]

, 2017
Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome.
Cooper, David Neil, Frayling, Ian Martin, Philpott, Charlotte, Tovell, Hannah, Upadhyaya, Meena   +4 more
core   +2 more sources

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source