Results 111 to 120 of about 102,686 (380)

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]

, 2015
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss, Benjamini, Blair R. Leavitt, Douglas Langbehn, Douglas Macdonald, Edward J. Wild, Henrik Zetterberg, James R.C. Miller, Jeromin, Ko, Lewczuk, Nicola Robertson, Rainer Kuhn, Roberto Boggio, Rosengren, Salman Haider, Sarah J. Tabrizi   +16 more
core   +1 more source

Facilitating Huntington's disease research: plasma neurofilament levels as a promising enrichment biomarker for HD-ISS stage 1 [PDF]

, 2023
Cristina Sampaio, Hilary Wilkinson
openalex   +1 more source

Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest

JAMA Neurology, 2019
Importance Prognostication of neurologic outcome after cardiac arrest is an important but challenging aspect of patient therapy management in critical care units. Objective To determine whether serum neurofilament light chain (NFL) levels can be used for
M. Moseby-Knappe, N. Mattsson, N. Nielsen, H. Zetterberg, K. Blennow, J. Dankiewicz, Irina Dragancea, H. Friberg, G. Lilja, P. Insel, C. Rylander, E. Westhall, J. Kjaergaard, M. Wise, C. Hassager, M. Kuiper, P. Stammet, M. Wanscher, J. Wetterslev, D. Erlinge, J. Horn, T. Pellis, T. Cronberg   +22 more
semanticscholar   +1 more source

Serum neurofilament light as a biomarker in progressive multiple sclerosis

Neurology, 2020
There is an unmet need in multiple sclerosis (MS) therapy for treatments to stop progressive disability. The development of treatments may be accelerated if novel biomarkers are developed to overcome the limitations of traditional imaging outcomes ...
R. Kapoor, Kathryn E Smith, M. Allegretta, D. Arnold, W. Carroll, M. Comabella, R. Furlan, Christopher T Harp, J. Kuhle, D. Leppert, T. Plavina, F. Sellebjerg, C. Sincock, C. Teunissen, Ilir Topalli, F. von Raison, Elizabeth Walker, R. Fox   +17 more
semanticscholar   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Functional and Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels

Medicina
Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient ...
Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis   +8 more
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]

, 2020
The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David, deCarvalho, Mamede, Grosskreutz, Julian, Kiernan, Matthew C, Leigh, P Nigel, Swash, Michael, Turner, Martin R   +6 more
core   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Soluble biomarkers for Neuromyelitis Optica Spectrum Disorders: a mini review

Frontiers in Neurology
The Neuromyelitis Optica Spectrum Disorders (NMOSD) constitute a spectrum of rare autoimmune diseases of the central nervous system characterized by episodes of transverse myelitis, optic neuritis, and other demyelinating attacks.
Rachel E. Rodin, Rachel E. Rodin, Tanuja Chitnis, Tanuja Chitnis   +3 more
doaj   +1 more source