Results 341 to 350 of about 102,686 (380)

Neurofilament phosphorylation

Biochemistry and Cell Biology, 1995
Neurofilament proteins (NFPs) are highly phosphorylated molecules in the axonal compartment of the adult nervous system. The phosphorylation of NFP is considered an important determinant of filament caliber, plasticity, and stability. This process reflects the function of NFs during the lifetime of a neuron from differentiation in the embryo through ...
H C, Pant, , Veeranna
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Interference with kinesin‐based anterograde neurofilament axonal transport increases neurofilament‐neurofilament bundling

Cytoskeleton, 2012
AbstractNeurofilaments (NFs) associate with each other and with other cytoskeletal elements to form a lattice that supports the mature axon. Phosphorylation contributes to formation of this stationary population of NFs by fostering cation‐dependent interactions among NF sidearms.
Neethu, Sunil, Sangmook, Lee, Thomas B, Shea   +2 more
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Substructures of neurofilaments

Acta Neuropathologica, 1984
The results of this investigation indicate that neurofilaments of mammals (human and rabbit) are composed of four protofilaments each of which is formed of globular units connected by longitudinal bars. A cross-view of neurofilaments reveals the presence of four globular units, 20-25 A in diameter, connected by four transverse bars, 25-30 A in length ...
G Y, Wen, H M, Wisniewski
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C‐terminal neurofilament phosphorylation fosters neurofilament–neurofilament associations that compete with axonal transport

Cytoskeleton, 2010
AbstractNeurofilaments (NFs) associate with each other and with other cytoskeletal elements to form a lattice that supports the mature axon. Phosphorylation contributes to formation of this structure by fostering cation‐dependent interactions among NF sidearms. By inducing NF bundling, phosphorylation impedes their axonal transport.
Sangmook, Lee, Neethu, Sunil, Thomas B, Shea   +2 more
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Neurofilaments and neurological disease

BioEssays, 2003
AbstractNeurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post‐translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells.
Al-Chalabi, A, Miller, C C J
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Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments

Brain Research, 2000
Neurofilaments are composed of three polypeptide subunits (NF-H, NF-M and NF-L). They are the most abundant cytoskeletal element in large myelinated axons and play a central role in development of axonal caliber. To perform this role, neurofilaments are transported from their site of synthesis, the cell bodies, to the distal axons.
Z, Xu, V W, Tung
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NEUROFILAMENT ANTIGENS IN ACRYLAMIDE NEUROPATHY.

Journal of Neuropathology and Experimental Neurology, 1987
After repeated exposure, acrylamide (AC) produces degeneration of distal axons. Because neurons whose axons have been injured (e.g. by axotomy) show alterations in their structural and chemical properties, the present study was designed to differentiate the direct effects of AC intoxication from neuronal responses secondary to axonal injury caused by ...
B G, Gold, D L, Price, J W, Griffin, J, Rosenfeld, P N, Hoffman, N H, Sternberger, L A, Sternberger   +6 more
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Structural Properties of Neurofilament Sidearms: Sequence-Based Modeling of Neurofilament Architecture

Journal of Molecular Biology, 2009
Neurofilaments (NFs) are essential cytoskeletal filaments that impart mechanical integrity to nerve cells. They are assembled from three distinct molecular mass proteins that bind to each other to form a 10-nm-diameter filamentous rod with sidearm extensions.
Rakwoo, Chang, Yongkyu, Kwak, Yeshitila, Gebremichael   +2 more
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Expanded Polyglutamine Domain Proteins Bind Neurofilament and Alter the Neurofilament Network

Experimental Neurology, 1999
Eight inherited neurodegenerative diseases are caused by genes with expanded CAG repeats coding for polyglutamine domains in the disease-producing proteins. The mechanism by which this expanded polyglutamine domain causes neurodegenerative disease is unknown, but nuclear and cytoplasmic polyglutamine protein aggregation is a common feature.
Y, Nagai, O, Onodera, J, Chun, W J, Strittmatter, J R, Burke   +4 more
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Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD

Neurology, 2019
Objective To test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are an intermediate astrocyte and neuron filaments, respectively, are clinically useful biomarkers of disease activity
Mitsuru Watanabe, Yuri Nakamura, Z. Michalak, N. Isobe, Christian Barro, D. Leppert, T. Matsushita, F. Hayashi, R. Yamasaki, J. Kuhle, J. Kira   +10 more
semanticscholar   +1 more source