Results 351 to 360 of about 102,686 (380)
Some of the next articles are maybe not open access.
Annals of the New York Academy of Sciences, 2009
Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
openaire +3 more sources
Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
openaire +3 more sources
Neurofilaments in diabetic neuropathy
2002This review discusses the role of abnormal neurofilament (NF) expression, processing, and structure as an etiological factor in diabetic neuropathy. Diabetic sensory and autonomic neuropathy in humans is associated with a spectrum of structural changes in peripheral nerve that includes axonal degeneration, paranodal demyelination, and loss of ...
Paul, Fernyhough, Robert E, Schmidt
openaire +2 more sources
Phosphorylation of neurofilament H subunit as related to arrangement of neurofilaments
Journal of Neuroscience Research, 1994AbstractTo find out what causes differences in phosphorylation states in neurofilaments (NF), we selected two types of dendrite, one provided with very few NFs (Purkinje cell) and the other with relatively many (anterior horn cell). We examined these with four monoclonal antibodies selected by the Western blot analysis, two (NE14 and SMI31 ...
T, Gotow, J, Tanaka
openaire +2 more sources
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
Journal of Neurology Neurosurgery & Psychiatry, 2018Objective To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre, prospective, longitudinal study included the following patients: 124 patients ...
F. Verde +17 more
semanticscholar +1 more source
Neurofilaments and glial filaments
Tissue and Cell, 1970The structure of neurofilaments and glial filaments are compared. Both filaments are composed of three subunits-a globule, interconnecting crossbar and side-arms. These elements form a tubular arrangement and their dimensions are given. Since the subunits of both filaments have a similar arrangement but differ in size, it is concluded that they ...
openaire +2 more sources
Phosphorylation protects neurofilaments against proteolysis
Journal of Neuroimmunology, 1987During incubation with phosphatase, the 200 kDa neurofilament protein in cytoskeletal preparations is degraded extensively. Degradation, which is divalent cation-independent, does not occur when inhibitors of phosphatase are added. The 160 kDa chymotryptic fragment of neurofilaments or affinity-purified 200 kDa protein are not degraded by phosphatase ...
M E, Goldstein +2 more
openaire +2 more sources
Neurofilaments in neurologic disease
Neurofilaments (NFs), major cytoskeletal constituents of neurons, have emerged as universal biomarkers of neuronal injury. Neuroaxonal damage underlies permanent disability in various neurological conditions. It is crucial to accurately quantify and longitudinally monitor this damage to evaluate disease progression, evaluate treatment effectiveness ...Christina, Mousele +2 more
openaire +2 more sources
Neurofilament triplet proteins
1999Abstract The neurofilament triplet proteins (i.e. the low, middle, and high molecular weight neurofilament proteins NF-L, NF-M, and NF-H) are the most abundant cytoskeletal components found in neurones and their precursor cells. In vivo they assemble into obligate heteropolymeric filaments that, different from the other intermediate ...
Harald Herrmann, Ueli Aebi
openaire +1 more source