Results 11 to 20 of about 1,367 (175)

Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real-world clinical practice. [PDF]

Epileptic Disord
Abstract Objective Patients with drug‐resistant epilepsy (DRE) typically take multiple anti‐seizure medications (ASMs) and are at risk of treatment‐related adverse events (AEs). This study assessed the impact of cenobamate monotherapy or dual therapy in patients with drug‐resistant epilepsy.
Benavente ÁS, Martín GG, Ruiz EDC, García PC, Moreno YL, María JCE, Fuentes IL, Conti SN, Calle RC, Cabrera AF, González IR, Blanco DC, Muñoz MIC, Castro PJS.   +13 more
europepmc   +2 more sources

Impact of Treatment Delays in Epileptic Seizures: Time to Hospital Care and to EEG Increases Risk of Status Epilepticus and ICU Admission in Epileptic Seizures. [PDF]

Eur J Neurol
Delays in urgent care for epileptic seizures, including prehospital transport and EEG performance, are associated with a higher risk of status epilepticus (SE) and ICU admission. Our study analyzed key time intervals in emergency management and found that prolonged transfer times and delayed EEG accessibility significantly impact patient outcomes ...
Sala Padró J, Fonseca E, Quintana M, Hernández Pérez G, López-Maza S, Campos-Fernández D, Abraira L, Santamarina E, Veciana de Las Heras M, Falip Centellas M, Toledo M.   +10 more
europepmc   +2 more sources

Quality of Relationships between Informal Caregivers and Patients with Mild Cognitive Impairment [PDF]

Alzheimers Dement
Abstract Background The quality of the caregiver‐patient relationship is essential for both parties, as it significantly influences the emotional well‐being of patients, and the satisfaction and burden of caregivers. This study aimed to assess the quality of caregiver‐patient relationships in informal caregivers of patients with mild cognitive ...
Sanchez‐Juan P, Arcelay E, Almagro M, Balasa M, Piñol‐Ripoll G, Boada M, Landete L, Abellán I, Berbel A, Espejo B, Baquero M, Marin J, Franco‐Macías E, Galende A, Fernandez F, Vilar I, Pérez‐Vieitez C, Rodriguez‐Espinosa N, Puig‐Pijoan A, Pizarro E, Rodríguez E, Rodrígo J, Mauriño J, Manzano M.   +23 more
europepmc   +2 more sources

Manifolds in the Medial Premotor Cortex During Switching From Attending to Tapping to a Metronome. [PDF]

Ann N Y Acad Sci
Low‐dimensional manifolds emerged in neural populations of the medial premotor cortex of macaque monkeys while they performed an attend‐then‐synchronize tapping task with periodic visual stimuli. The neural dynamics followed an increasingly oscillatory trajectory from attending to tapping stages of the trial (left panel).
Dotov D, Betancourt A, Gámez J, Merchant H.   +3 more
europepmc   +2 more sources

Olfactory impairment is related to REM sleep deprivation in rotenone model of Parkinson's disease [PDF]

Sleep Science
Introduction: Olfactory dysfunction affects about 85-90% of Parkinson's disease (PD) patients with severe deterioration in the ability of discriminate several types of odors. In addition, studies reported declines in olfactory
Mariana F. Aurich, Lais S. Rodrigues, Adriano D. S. Targa, Ana Carolina D. Noseda, Flávia D. W. Cunha, Marcelo M. S. Lima   +5 more
doaj   +1 more source

5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development

Scientific Reports, 2022
Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis.
Guilherme Shigueto Vilar Higa, José Francis-Oliveira, Estevão Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Ianê Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasquale   +9 more
doaj   +1 more source

A randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactions Ensaio clínico sobre o tratamento com esteróides via oral da neuropatia ulnar em reação tipo 1 e tipo 2 da hanseníase

Arquivos de Neuro-Psiquiatria, 2008
BACKGROUND: Steroids regimens in leprosy neuropathies are still controversial in botth types of reactions. METHOD: For this trial, 21 patients with ulnar neuropathy were selected from 163 leprosy patients, 12 with type 1 reaction (T1R) and nine with type
José Antonio Garbino, Marcos da Cunha Lopes Virmond, Somei Ura, Manoel Henrique Salgado, Bernard Naafs   +4 more
doaj   +1 more source

The invisible scars of emotional abuse: a common and highly harmful form of childhood maltreatment

BMC Psychiatry, 2021
Background Childhood maltreatment (CM) is unfortunately widespread globally and has been linked with an increased risk of a variety of psychiatric disorders in adults, including posttraumatic stress disorder (PTSD).
Camila Monteiro Fabricio Gama, Liana Catarina Lima Portugal, Raquel Menezes Gonçalves, Sérgio de Souza Junior, Liliane Maria Pereira Vilete, Mauro Vitor Mendlowicz, Ivan Figueira, Eliane Volchan, Isabel Antunes David, Leticia de Oliveira, Mirtes Garcia Pereira   +10 more
doaj   +1 more source

Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia

Parkinson's Disease, 2012
In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the ...
Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Barbara Picconi, Paolo Calabresi   +4 more
doaj   +1 more source

Estudos de condução nervosa no nervo tibial através do túnel do tarso em pacientes de hanseníase

Hansenologia Internationalis, 2015
Os autores avaliaram todos os exames de condução nervosa do nervo tibial dos pacientes com suspeita de neuropatia da hanseníase, aguda ou subaguda, atendidos no Ambulatório de Hansenologia do Instituto Lauro de Souza Lima (ILSL) no período de dois anos.
Gustavo Guilherme Ruschel Robinson, Paula Levatti Alexandre, Daniel Rocco Kirchner, José Antonio Garbino   +3 more
doaj   +1 more source