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2018
Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are ...
Runrui Zhang, Anna Engler, Verdon Taylor
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Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are ...
Runrui Zhang, Anna Engler, Verdon Taylor
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Developmental Neuroscience, 1997
NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in the nervous system.
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NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in the nervous system.
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2006
Adult neurogenesis is the generation of new neurons in the adult brain. Adult neurogenesis is an exception, as the brain of mammals is non-neurogenic. Rodents and primates have two neurogenic zones, the hippocampus and the olfactory bulb. Lower vertebrates often have many more sites of adult neurogenesis. In the peripheral nervous system, there is high
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Adult neurogenesis is the generation of new neurons in the adult brain. Adult neurogenesis is an exception, as the brain of mammals is non-neurogenic. Rodents and primates have two neurogenic zones, the hippocampus and the olfactory bulb. Lower vertebrates often have many more sites of adult neurogenesis. In the peripheral nervous system, there is high
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Journal of Cellular and Comparative Physiology, 1962
A consideration of neurogenesis touches on several basic problems of cell differentiation and cell interactions. The great diversity of neuron types supplies us with an abundant material for the study of the origin of cell strain specificity. Cell interactions occur during neurogenesis in a great variety of situations, and in all of them, problems of ...
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A consideration of neurogenesis touches on several basic problems of cell differentiation and cell interactions. The great diversity of neuron types supplies us with an abundant material for the study of the origin of cell strain specificity. Cell interactions occur during neurogenesis in a great variety of situations, and in all of them, problems of ...
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CNS & Neurological Disorders - Drug Targets, 2007
Stroke stimulates neurogenesis in select regions of the adult brain, and the newborn neurons that result can migrate to areas of ischemic injury, where they may have the capacity to enhance brain recovery. These observations suggest that stroke-induced neurogenesis may contribute to endogenous brain repair after stroke, and that the mechanisms that ...
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Stroke stimulates neurogenesis in select regions of the adult brain, and the newborn neurons that result can migrate to areas of ischemic injury, where they may have the capacity to enhance brain recovery. These observations suggest that stroke-induced neurogenesis may contribute to endogenous brain repair after stroke, and that the mechanisms that ...
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Perspectives on adult neurogenesis
European Journal of Neuroscience, 2011New neurons are generated throughout life. This discovery has challenged firmly held concepts about the structural plasticity and regenerative capacity of the mammalian brain. In this special issue of the EJN, leaders in the field summarize and review recent advances aiming to understand the molecular mechanisms underlying adult neurogenesis and the ...
Knobloch Marlen, Jessberger Sebastian
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Biochemical Pharmacology, 2017
The brain has long been known as a dimorphic organ and as a target of sex steroids. It is also a site for their synthesis. Sex steroids in numerous ways can modify cerebral physiology, and along with many processes adult neurogenesis is also modulated by sex steroids.
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The brain has long been known as a dimorphic organ and as a target of sex steroids. It is also a site for their synthesis. Sex steroids in numerous ways can modify cerebral physiology, and along with many processes adult neurogenesis is also modulated by sex steroids.
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Hippocampal Neurogenesis and Ageing
2012Although significant inconsistencies remain to be clarified, a role for neurogenesis in hippocampal functions, such as cognition, has been suggested by several reports. Yet, investigation in various species of mammals, including humans, revealed that rates of hippocampal neurogenesis are steadily declining with age.
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