Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography [PDF]
, 2007 Jun Maeda +13 more
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li +11 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Our study used behavioral tests, laser speckle flowmetry, long‐term potentiation, histochemical staining, molecular experiments, and voxel‐based morphometry to evaluate the hippocampal impairments. It demonstrates early functional and structural impairments in the hippocampus contributing to learning and memory deficits after 1 month of BCAS ...
Ping Tang +3 more
wiley +1 more source
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia [PDF]
, 2008 Eduardo Candelario‐Jalil +2 more
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Animal Models and Experimental Medicine, EarlyView.Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam +13 more
wiley +1 more source
Absence of the Cellular Prion Protein Exacerbates and Prolongs Neuroinflammation in Experimental Autoimmune Encephalomyelitis [PDF]
, 2008 Shigeki Tsutsui +4 more
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Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation
Animal Models and Experimental Medicine, EarlyView.Laryngeal muscle evoked potentials (LMEPs) reflect the activation of laryngeal muscles induced by vagus nerve stimulation (VNS) via vagal Aα‐motor fibers. LMEP recordings are minimally invasive and provide a feasible, reliable method for assessing the integrity of the electrode‐nerve interface during experimental VNS in rodents.
Helen Bachmann +3 more
wiley +1 more source
Ultra-Low-Dose Naloxone Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in PTX-Treated Rats [PDF]
, 2008 Ru‐Yin Tsai +5 more
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Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
Animal Models and Experimental Medicine, EarlyView.In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong +7 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary aim of this study was to use a mouse model and the intrabuccal route for CBD administration to determine the optimal dose at ...
Oluwadara Pelumi Omotayo +4 more
wiley +1 more source