Results 171 to 180 of about 308,337 (381)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile

BMJ Open
Purpose Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substantially
, Baris Kanber, Alan J Thompson, Jeremy Chataway, Frederik Barkhof, Bhavana Solanky, Marios Yiannakas, Olga Ciccarelli, Heather Wilson, Yael Hacohen, Sarah Wright, Karen Chung, Arman Eshaghi, Le Zhang, Declan Chard, Jonathan Stutters, Ferran Prados Carrasco, Claudia Angela Gandini Wheeler-Kingshott, Floriana De Angelis, Charmaine Yam, Zhaleh Khaleeli, Marcello Moccia, Anuriti Aojula, Samih Fourali, Ahmed Toosy, Josephine Swanton, Alessia Bianchi, Wallace Brownlee, Siobhan Leary, Sarmad Al-Araji, Olivia Goodkin, Anna He, Sara Collorone, Valeria Pozzilli, Suraya Mohamud, Ronja Christensen, Alessandro Cruciani, Weaam Hamed, Ahmed Hammam, Davide Maccarrone, Riccardo Nistri, Anestis Passalis, Eirini Samdanidou, Joy Song, Jed Wingrove, Dimitrios Champas, Mohammad Kurd, Elena Panella, Fatima Pansari, Alyssa Toorop, Anand Trip, Chloe Parker, Michaela Stuart, Hanne Haagenrud   +53 more
doaj   +1 more source

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression [PDF]

, 2018
Patrick Lowe, Benedek Gyöngyösi, Abhishek Satishchandran, Arvin Iracheta‐Vellve, Yeonhee Cho, Aditya Ambade, Gyöngyi Szabó   +6 more
openalex   +1 more source

Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration

Nature Metabolism, 2023
Yashi Mi, Guoyuan Qi, F. Vitali, Yuan Shang, A. Raikes, Tian Wang, Yan Jin, R. Brinton, Haiwei Gu, F. Yin   +9 more
semanticscholar   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome

Frontiers in Psychiatry, 2018
Fatigue is commonly reported in a variety of illnesses and has major impact on quality of life. Chronic fatigue syndrome (CFS) is a debilitating syndrome of unknown etiology. The clinical symptoms include problems in neuroendocrine, autonomic, and immune
Mami Noda, Masataka Ifuku, Md. Shamim Hossain, Toshihiko Katafuchi   +3 more
doaj   +1 more source

Effects of TRAM-34 and minocycline on neuroinflammation caused by diabetic ketoacidosis in a rat model [PDF]

, 2022
Nicole Glaser, Steven Chu, J. Howard Weiner, Linnea Zdepski, Heike Wulff, Daniel J. Tancredi, Martha E. O’Donnell   +6 more
openalex   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Intrathecal B-cell activation in LGI1 antibody encephalitis. [PDF]

, 2020
ObjectiveTo study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a ...
Dandekar, Ravi, Gelfand, Jeffrey M, Geschwind, Michael D, Greenfield, Ariele L, Irani, Sarosh R, Jahn, Sarah, Lehmann-Horn, Klaus, Lepennetier, Gildas, Michael, Sophia, Palanichamy, Arumugam, von Büdingen, H-Christian, Wang, Shengzhi, Wilson, Michael R, Zamvil, Scott S   +13 more
core  

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source