Results 181 to 190 of about 252,991 (337)
Progressive Increase in Infarct Size, Neuroinflammation, and Cognitive Deficits in the Presence of High Levels of Amyloid [PDF]
, 2007 Shawn N. Whitehead +3 more
openalex +1 more source
Advanced Science, EarlyView.The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie +8 more
wiley +1 more source
Advanced Science, EarlyView.SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang +13 more
wiley +1 more source
Advanced Science, EarlyView.Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu +5 more
wiley +1 more source
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinsons Disease [PDF]
, 2007 Randy L. Hunter, Guoying Bing
openalex +1 more source
Advanced Science, EarlyView.CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee +13 more
wiley +1 more source
Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism [PDF]
, 2008 Alexander Semmler +9 more
openalex +1 more source
Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia [PDF]
, 2008 Eduardo Candelario‐Jalil +2 more
openalex +1 more source