Results 291 to 300 of about 240,724 (351)

Neuronal surface and intracellular antibody testing in patients with long‐term epilepsy

Epilepsia Open, EarlyView.
Abstract Objective We aimed to investigate the frequency of neuronal surface and intracellular antibodies in individuals with long‐term epilepsy and the associated clinical and laboratory characteristics. Methods We tested sera from 223 patients with epilepsy without signs of autoimmune encephalitis and 12 patients with epilepsy and a subacute onset of
Nancy Watanabe, Angelica Lizcano, Tânia K. de Araujo, Renata Barbosa, Marina K. M. Alvim, Andre S. Vieira, Iscia Lopes‐Cendes, Fabio Rogerio, Clarissa L. Yasuda, Fernando Cendes   +9 more
wiley   +1 more source

CCL2 Inhibitor Bindarit Improve Postoperative Cognitive Function by Attenuating Pericyte Loss-Related Blood-Brain Barrier Disruption and Neuroinflammation. [PDF]

Mediators Inflamm
Yuan H, Lu B, Sun D, Chen J, Fang X.
europepmc   +1 more source

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

Exploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan   +9 more
wiley   +1 more source

The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms. [PDF]

Front Cell Infect Microbiol
Xie W, Yan X, Yang X, Sun H, Zhang W.
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Nutritional Modulation of Impaired Blood-Brain Barrier Integrity and Function in Major Depression. [PDF]

Int J Mol Sci
Adzic M, Lukic I, Mitic M, Zerajic EF, Glavonic E, Jovanovic M, Ivkovic S.   +6 more
europepmc   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

An Updated and Comprehensive Review Exploring the Gut-Brain Axis in Neurodegenerative Disorders and Neurotraumas: Implications for Therapeutic Strategies. [PDF]

Brain Sci
Hasan A, Scuderi SA, Capra AP, Giosa D, Bonomo A, Ardizzone A, Esposito E.   +6 more
europepmc   +1 more source

Rev-erbs and glia—implications for neurodegenerative diseases [PDF]

, 2019
Dimitry, Julie M., Griffin, Percy, Musiek, Erik S.   +2 more
core   +1 more source

Synergistic Effects of Ginsenoside Rb3 and Rc From Panax notoginseng Leaf on Alleviating Neuroinflammation via PACAP in Depression

Food Frontiers, EarlyView.
EPL relieves depressive‐like behaviors by upregulating hippocampal PACAP via Rb3/Rc synergy, showing dual modulation of synaptic plasticity and neuroinflammation. ABSTRACT Panax notoginseng Leaf (PNL), an edible‐medicinal botanical resource, shows potential as functional ingredients for alleviating depression, owing to their unique saponin composition.
Shu‐zhen Ran, Rui Peng, Qin‐wan Guo, Li‐juan Ma, Jian‐bo Wan, Jun‐qing Huang, Zi‐ying Wang, Gang Chen   +7 more
wiley   +1 more source