Results 201 to 210 of about 12,605,538 (213)

The overexpression of neurokinin B–neurokinin 3 receptor system exerts direct effects on the ovary under PCOS‐like conditions to interfere with mitochondrial function

American Journal of Reproductive Immunology, 2022
The increased hypothalamic neurokinin B (NKB) level may contribute to the hyperactive LH pulse secretion in Polycystic ovary syndrome (PCOS). However, the expression and role of the neurokinin B‐neurokinin 3 receptor (NKB‐NK3R) system in the local ...
Fei Guo, T. Fernando, Xiaoyong Zhu, Yingli Shi   +3 more
semanticscholar   +1 more source

Interactions of neurokinin B with copper(II) ions and their potential biological consequences.

Dalton Transactions, 2022
Preeclampsia is a blood pressure disorder associated with significant proteinuria. Hypertensive women have increased levels of neurokinin B (NKB) and Cu(II) ions in blood plasma during pregnancy. NKB bears the ATCUN/NTS N-terminal motif empowering strong
Kamila Stokowa-Sołtys, Klaudia Szczerba, Magdalena Pacewicz, R. Wieczorek, N. E. Wezynfeld, W. Bal   +5 more
semanticscholar   +1 more source

Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt

Biology of Reproduction, 2021
Puberty onset is a complex physiological process, which enables the capacity for reproduction through increased gonadotropin-releasing hormone and subsequently luteinizing hormone secretion.
K. Harlow, Allison N Renwick, Sydney L. Shuping, Jeffrey R. Sommer, C. Lents, M. Knauer, Casey C Nestor   +6 more
semanticscholar   +1 more source

Central injection of neuropeptide Y modulates sexual behavior in male rats: interaction with GnRH and kisspeptin/neurokinin B/dynorphin

International Journal of Neuroscience, 2020
Aims A number of studies have shown that neuropeptide Y (NPY) is considered to be one of the key regulators of hypothalamic-pituitary-gonadal (HPG) axis in the mammals.
V. Azizi, S. Oryan, Homayuon Khazali, A. Hosseini   +3 more
semanticscholar   +1 more source

More promising news (mostly) on manipulating neurokinin B activity as a nonhormonal treatment of hot flashes.

Menopause, 2020
severe VMS are notoriously prominent. Competition is G enerally when it comes to human biology most things shrink as we age—from bones, to gonads, to brains—and in the case of women, ‘‘getting old’’ is accelerated by estrogen (E) loss at menopause.
N. Reame
semanticscholar   +1 more source

The role of kisspeptin/neurokinin B/dynorphin neurons in pathomechanism of vasomotor symptoms in postmenopausal women: from physiology to potential therapeutic applications

Gynecological Endocrinology, 2018
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65–75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats ...
A. Szeliga, A. Czyżyk, A. Podfigurna, A. Genazzani, A. Genazzani, B. Męczekalski   +5 more
semanticscholar   +1 more source

Kisspeptin and Neurokinin B: roles in reproductive health.

Physiological Reviews
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause.
K. Koysombat, J. Tsoutsouki, A. Patel, A. Comninos, W. Dhillo, A. Abbara   +5 more
semanticscholar   +1 more source

Neurokinin B and Neurokinin-3 Receptor Signaling: Promising Developments in the Management of Menopausal Hot Flushes

Seminars in Reproductive Medicine, 2019
Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being.
M. Modi, W. Dhillo
semanticscholar   +1 more source

The potential implication of neurokinin B in the modulation of prolactin secretion at the pituitary level in cyclic gilts.

Journal of Physiology and Pharmacology, 2020
W. Czelejewska, A. Zmijewska, M. Dziekoński, S. Okrasa   +3 more
semanticscholar   +1 more source

Assessment of Relationship of Serum Neurokinin-B Level in the Pathophysiology of Pre-eclampsia: A Case–Control Study

Advances in Therapy, 2018
H. Salman, Mohsin Shah, Asif Ali, A. Aziz, S. Vitale   +4 more
semanticscholar   +1 more source