Results 131 to 140 of about 929,659 (335)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang +11 more
wiley +1 more source
Neurobiology of Disease, 2019 Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease caused by a CAG expansion, which translates into an elongated polyglutamine (polyQ) repeat near the amino-terminus of the huntingtin protein (HTT).
Lisa M. Stanek +2 more
doaj +1 more source
Communications Biophysics [PDF]
, 1959 Contains reports on two research projects.United States Air Force (Contract AF19(604)-4112)United States National Institute of Neurological Diseases and Blindness, U.S.
Barlow, J. S., Goldstein, M. H., Jr.
core
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
eLife, 2018 Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of
Gian-Luca McLelland +12 more
doaj +1 more source
Neurology and Psychiatry in Childhood Proceedings of the Association for Research in Nervous and Mental Disease, Vol. XXXIV [PDF]
, 1956 openalex +1 more source
Neurological diseases in pregnancy
Journal of the Royal College of Physicians of Edinburgh, 2013 Neurological diseases are a major cause of morbidity and mortality in pregnancy. The management of multiple sclerosis, epilepsy, myasthenia gravis, certain neuropathies and headache in pregnancy is described; the potentially life-threatening conditions of stroke and eclampsia are also discussed. Management of most neurological conditions is similar to
Lucy Mackillop, Devaang Kevat
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li +10 more
wiley +1 more source
Acute microglia ablation induces neurodegeneration in the somatosensory system
Nature Communications, 2018 Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and ...
Stephen J. Rubino +14 more
doaj +1 more source