Results 161 to 170 of about 1,670,654 (326)

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Towards Transforming Neurorehabilitation: The Impact of Artificial Intelligence on Diagnosis and Treatment of Neurological Disorders

Biomedicines
Background and Objectives: Neurological disorders like stroke, spinal cord injury (SCI), and Parkinson’s disease (PD) significantly affect global health, requiring accurate diagnosis and long-term neurorehabilitation.
Andrea Calderone, Desirée Latella, M. Bonanno, A. Quartarone, Sepehr Mojdehdehbaher, A. Celesti, R. S. Calabrò   +6 more
semanticscholar   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Impact of AI-Powered Solutions in Rehabilitation Process: Recent Improvements and Future Trends

International Journal of General Medicine
Rehabilitation is an important and necessary part of local and global healthcare services along with treatment and palliative care, prevention of disease, and promotion of good health. The rehabilitation process helps older and young adults even children
Umamah bint Khalid, Muddasar Naeem, F. Stasolla, M. Syed, Musarat Abbas, Antonio Coronato   +5 more
semanticscholar   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

A prospective quasi-experimental controlled study evaluating the use of defo to manage common postpartum ailments during postnatal care [PDF]

, 1998
Milne, Nikki, Rathbone, Evelyne, Szkwara, Jaclyn   +2 more
core   +2 more sources

Five functional domains associated with gait performance in Parkinson’s disease and lateral trunk flexion

Frontiers in Neurology
BackgroundLateral trunk flexion (LTF) is a common symptom of Parkinson’s disease (PD). The sensory re-weighting system and sensory-motor function are poor in patients with PD and LTF, and this may cause gait impairment.
Keisuke Ota, Hiroki Mani, Keita Nochimura, Yuichi Nakashiro, Shinsuke Hamada, Fumio Moriwaka   +5 more
doaj   +1 more source

Validity of the Early Functional Ability scale (EFA) among critically ill patients undergoing early neurological rehabilitation. [PDF]

BMC Neurol, 2022
Boltzmann M, Schmidt SB, Gutenbrunner C, Krauss JK, Höglinger GU, Weimar C, Rollnik JD.   +6 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Early Multidisciplinary Rehabilitation Improves Swallowing and Speech Function in a Patient With Amyotrophic Lateral Sclerosis

Clinical Case Reports
Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease for which there is a lack of effective treatment. This case report describes a 49‐year‐old male with ALS who presented with dysphagia, dysarthria, dyskinesia, sleep ...
Yue Hu, Yun Lu, Danmei Lan
doaj   +1 more source