Results 11 to 20 of about 996,320 (184)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Evaluation of dosimetric and spatial accuracy of a virtual cone technique for radiosurgery using linac‐integrated CBCT‐based polymer gel dosimetry

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study evaluates the dosimetric and geometric precision of a virtual cone technique using CBCT‐based polymer gel dosimetry, enabling radiation delivery, and imaging readout within an identical spatial coordinate system. Methods We created a C# script for a virtual cone technique that generates a treatment plan with 10 gantry arcs ...
Tenzin Kunkyab, Michael Lamey, Andrew Jirasek, Michael Kudla, Nathan Becker, Benjamin Mou, Derek Hyde   +6 more
wiley   +1 more source

Síndrome de pessoa-rígida e ataxia cerebelar com teste anti-GAD positivo: duas condições clínicas tratáveis as quais o médico deve permanecer atento [PDF]

, 2012
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Neurology, Movement Disorders UnitUNIFESP, EPM, Neurology, Movement Disorders ...
Ferraz, Henrique Ballalai
core   +2 more sources

Empowering young minds through STEM education: Engaging high schoolers in Ghana through medical physics

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To promote diversity in Science, Technology, Engineering, and Mathematics (STEM), an educational presentation and hands‐on session was organised to raise awareness of STEM career opportunities among high school girls to introduce the students to the field of medical physics. Materials and Methods The study involved 65 first‐year Senior
Afua A. Yorke, Mercy T. Schandorf, Abigail N. M. Quaye, Peniel Tenkorama Twum, Bishwambhar Sengupta, Kwadwo Nkansah‐Poku, Juliana A. Kplorfia, Jessica Fagestrom   +7 more
wiley   +1 more source

DEVELOPMENT OF NEUROLOGY IN PAKISTAN. [PDF]

, 2013
On the eve of the 20th Annual Neurology Conference we can look back over the last two decades to assess the development of Neurology in Pakistan. Neurology first functioned under the banner of Pakistan Academy of Neurological Sciences (PANS) and then as ...
M. Alam, Sardar
core   +1 more source

Carbamazepine-responsive paroxysmal nausea and vomiting in a patient with meningeal carcinomatosis [PDF]

, 2006
In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapyrefractory nausea and vomiting.
Borasio, Gian Domenico
core   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

LINC00323 variant is associated with increased risk of essential tremor

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Essential tremor (ET) is a common adult movement disorder, with accumulating evidence suggesting that genetic factors primarily account for ET risk. However, replication studies on the genetic variants have yielded inconsistent results. In our case–control study, we show that the LINC00323 variant, identified in a European GWAS study, is ...
Brendan Tan, Ebonne Ng, Qiao Yang Sun, Aaron Mai, Ling‐Ling Chan, Thomas Welton, Kumar M. Prakash, Kay Yaw Tay, Wing Lok Au, Louis C.S. Tan, Eng‐King Tan, Bin Xiao   +11 more
wiley   +1 more source

Present and future of neurology in pakistan [PDF]

, 2016
Neurology started as a department in early nineteen sixties in Dow Medical College and King Edward Medical College and initially having a separate department of neurology was not mandated in medical colleges by Pakistan Medical and Dental Council¹.
Wasay, Mohammad
core   +1 more source

UDP‐glucose dehydrogenase variants cause dystroglycanopathy

Annals of Clinical and Translational Neurology, EarlyView.
Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs, Carrie M. Stephan, Theresa M. Czech, Mary O. Cox, Soumya Joseph, Benjamin W. Darbro, Steven A. Moore, Kevin P. Campbell, Katherine D. Mathews   +8 more
wiley   +1 more source