Results 221 to 230 of about 32,201 (250)

Neuromyelitis optica

Aktuelle Neurologie, 2012
The discovery of serum autoantibodies against the astrocytic water channel aquaporin-4 (AQP4) as a biomarker of neuromyelitis optica (NMO, Devic syndrome) has revolutionized our understanding of this rare immune-mediated clinical entity and has provided a rationale for the use of therapeutic strategies targeting the humoral effector arm of autoimmune ...
Friedemann Paul   +2 more
openaire   +5 more sources

Neuromyelitis optica

Nature Reviews Disease Primers, 2020
Neuromyelitis optica (NMO; also known as Devic syndrome) is a clinical syndrome characterized by attacks of acute optic neuritis and transverse myelitis. In most patients, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQP4), the most abundant water-channel protein in the central nervous system.
Sven, Jarius   +5 more
openaire   +4 more sources

Neuromyelitis optica and neuromyelitis optica spectrum disorders

Current Opinion in Neurology, 2017
Purpose of review The discovery of highly specific auto-antibodies directed against the water channel aquaporin 4 was a quantum leap in the definition, classification and management of neuromyelitis optica (NMO). Herein, we propose an update on epidemiological, clinical and therapeutic advances in the field, underlining unmet ...
Alvaro Cobo Calvo   +2 more
openaire   +5 more sources

Neuromyelitis Optica

Current Treatment Options in Neurology, 2010
Neuromyelitis optica (NMO) or Devic's disease typically involves the optic nerves and the spinal cord and is most often relapsing. The pathogenesis is one of an acute inflammatory process targeting astrocytes and resulting in demyelination, as well as axonal injury.
William M, Carroll, Kazuo, Fujihara
openaire   +2 more sources

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