<i>FCRL3</i> genetic variants drive autoimmune pathogenesis in multiple sclerosis and neuromyelitis optica spectrum disorders. [PDF]
Huang HF +6 more
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High-Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies-A Real-World Study. [PDF]
Li X +10 more
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Research hotspots and emerging topics in neuromyelitis optica spectrum disorder treatment: Insights from a bibliometric analysis. [PDF]
Wang J, Cai G, Xia S, Qin J, Liu B.
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Bilateral Ptosis, Diplopia, and Vertical Gaze Palsy: An Unusual Presentation of Adolescent Aquaporin-4 (AQP4)-Antibody Positive Neuromyelitis Optica Spectrum Disorder. [PDF]
Flayyih R, Abujouda A, Fathalla W.
europepmc +1 more source
Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and mixed connective tissue disease: a case report. [PDF]
Wang Z +5 more
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The discovery of serum autoantibodies against the astrocytic water channel aquaporin-4 (AQP4) as a biomarker of neuromyelitis optica (NMO, Devic syndrome) has revolutionized our understanding of this rare immune-mediated clinical entity and has provided a rationale for the use of therapeutic strategies targeting the humoral effector arm of autoimmune ...
Friedemann Paul +2 more
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Neuromyelitis optica (NMO; also known as Devic syndrome) is a clinical syndrome characterized by attacks of acute optic neuritis and transverse myelitis. In most patients, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQP4), the most abundant water-channel protein in the central nervous system.
Sven, Jarius +5 more
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Neuromyelitis optica and neuromyelitis optica spectrum disorders
Current Opinion in Neurology, 2017Purpose of review The discovery of highly specific auto-antibodies directed against the water channel aquaporin 4 was a quantum leap in the definition, classification and management of neuromyelitis optica (NMO). Herein, we propose an update on epidemiological, clinical and therapeutic advances in the field, underlining unmet ...
Alvaro Cobo Calvo +2 more
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Neuromyelitis optica (NMO) or Devic's disease typically involves the optic nerves and the spinal cord and is most often relapsing. The pathogenesis is one of an acute inflammatory process targeting astrocytes and resulting in demyelination, as well as axonal injury.
William M, Carroll, Kazuo, Fujihara
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